PMID: 8964042Apr 1, 1996Paper

Histochemical and ultrastructural study of the extracellular matrix fibers in patellar tendon donor site scars and normal controls

Journal of Submicroscopic Cytology and Pathology
C N BattlehnerG S Montes

Abstract

Lesions of the anterior cruciate ligament are extremely common and frequently demand surgical treatment in order to avoid disabling sequels. The use of a central one-third of the patellar tendon as an autograft for surgical reconstruction of a damaged cruciate ligament is common. Although several investigations in human and animal models have demonstrated long-term graft viability, there have been cases of loosening and rupture of the graft. In these occasions, a new substitute for the torn structure must be found. Owing to its inherent accessibility, the patellar tendon has been elected one of the choices of donor tissue. In order to evaluate the characteristics of the remaining scar, we performed a histochemical and ultrastructural study using biopsy material obtained from the central one-third of the donor tendon of 8 patients. This material was analyzed by comparing the ultrastructural picture with the results obtained using the specific method for collagen-containing fibers (Picrosirius-polarization) by light microscopy; four normal patellar tendons were used as controls. Despite the resemblance with the normal tissue, our results show that the healed tissue does not restore the tendon ad integrum, neither at the light mic...Continue Reading

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