PMID: 6112214Jan 1, 1981Paper

Histochemical characteristics of spontaneous and chemically induced hepatocellular neoplasms in mice and the development of neoplasms with gamma-glutamyl transpeptidase activity during phenobarbital exposure

The Histochemical Journal
T OhmoriG M Williams

Abstract

The histochemical characteristics of spontaneous hepatocellular neoplasms in mice of both sexes were examined and compared with those of hepatocellular neoplasms induced in female mice by administration of polycyclic aromatic hydrocarbon carcinogens as initiators with or without subsequent phenobarbitone treatment. Controls treated with phenobarbitone alone was also induced. Spontaneous neoplasms in the livers of mice rendered siderotic by subcutaneous iron injection were deficient in cellular accumulation of stainable iron. Glucose-6-phosphatase activity was deficient in the majority of spontaneous and induced neoplasms. ATPase activity was increase in about half of spontaneous and carcinogen-induced neoplasms but all induced neoplasms in mice treated with phenobarbitone showed deficient activity. Gamma-glutamyltransferase activity was present in very few of the spontaneous neoplasms or in the neoplasms induced in the absence of phenobarbitone administration. However, all induced neoplasms in the mice receiving phenobarbitone showed some degree of gamma-glutamyltransferase activity together with deficient glucose-6-phosphatase and ATPase activities. It is concluded that the histochemical characteristics of spontaneous or induc...Continue Reading

References

Sep 1, 1975·Journal of the National Cancer Institute·M M KalengayiV J Desmet
Jul 1, 1978·The Journal of Pathology·W H Butler, V Hempsall
Dec 1, 1972·Journal of the National Cancer Institute·W H Williams, R G Krueger
Jul 15, 1971·International Journal of Cancer. Journal International Du Cancer·M C Moulin, R Daoust
Jun 1, 1973·Food and Cosmetics Toxicology·A I WalkerD E Stevenson
Aug 1, 1969·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A M RutenburgA M Seligman
Sep 1, 1960·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M WACHSTEINA NIEDZWIEDZ

❮ Previous
Next ❯

Citations

May 1, 1986·Cancer Letters·R E Richmond, M A Pereira
Feb 1, 1982·Toxicologic Pathology·Peter BannaschHeide Zerban
Jan 1, 1996·Toxicologic Pathology·J M WardD E Devor
Sep 3, 1998·Molecular Carcinogenesis·U M WastlR Schulte-Hermann
Nov 5, 1997·Critical Reviews in Toxicology·S KnasmüllerR Schulte-Hermann
Nov 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J TazawaS W French
Jan 1, 1986·European Journal of Cancer & Clinical Oncology·A A StarkM Amizur
Jan 1, 1983·Toxicology and Applied Pharmacology·L KamdemD Zissu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
G Malvaldi
The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
K DempoW H Fishman
Xenobiotica; the Fate of Foreign Compounds in Biological Systems
A M Treston, W D Hooper
Bulletin of Environmental Contamination and Toxicology
K A BabuS K Chatterjee
© 2021 Meta ULC. All rights reserved