Histochemical characterization of monoamine oxidase in ependyma of rat hypothalamus

The Histochemical Journal
D WilliamsE D Williams

Abstract

Monoamine oxidase (MAO) activity has been demonstrated histochemically in rat hypothalamic ependyma using the sulphate-tetrazolium and coupled peroxidatic techniques with tryptamine, tyramine, 5-hydroxytryptamine and benzylamine as substrates. Both methods were applied to cryostat sections with and without exposure to selective amine oxidase inhibitors, including the selective A-MAO inhibitor clorgyline, and the B-MAO inhibitor deprenyl. Our results show that both cuboidal-columnar and tanycyte ependyma contain one or more forms of MAO not generally present in the hypothalamus. It is suggested that ependymal MAO may form an amine-barrier system modulating the movement and effect within the hypothalamus of specific cerebrospinal fluid or blood monoamines.

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Citations

Jan 1, 1988·Journal of Neural Transmission·J WilloughbyM Sandler
Apr 1, 1985·Brain Research·J E BruniR E Clattenburg
Jun 27, 2012·Journal of Neuroinflammation·Pramod Kumar Mishra, Judy M Teale
Jun 1, 1996·The Histochemical Journal·R J Van den Munckhof
Apr 1, 1986·Cell Biochemistry and Function·S Darracott-CankovicJ Chayen
Apr 29, 1998·Microscopy Research and Technique·J E Bruni

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