Histochemical correlation between glycogen, nucleic acids and nucleases in pre-neoplastic and neoplastic lesions of rat liver after short-term administration of N-nitrosomorpholine

Zeitschrift Für Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology
Henryk S Taper, P Bannasch


After 7 weeks of oral administration of the carcinogen N-nitrosomorpholine (12 mg NNM ad 100 ml of drinking water) to male rats, marked hepatocellular changes were found predominantly in the centers of the lobules. These were loss of glycogen, disorganisation of the basophilic bodies and, sometimes, loss of cytoplasmic basophilia or pyroninophilia, necrotic cells and increase in the activity of acid DNAse and RNAse. These centrilobular alterations were reversible after withdrawal of the carcinogen. They are, therefore, attributed to the nonspecific-toxic effect of the carcinogen. In peripheral and midzonal regions of the lobules basically different cellular changes appeared which were unimportant during the phase of intoxication, but became prominent after cessation of the carcinogenic treatment. These lesions were: excessive storage of glycogen, displacement of basophilic bodies and an increase in cytoplasmic acidophilia. The hepatocytes showing these cytoplasmic changes initially formed foci. Neoplastic nodules and frank hepatocellular carcinomas developed later. During these later stages of the experiment both the foci and the nodules consisted of 4 main types of altered hepatocytes: 1) "clear" glycogen storage cells, 2) aci...Continue Reading


May 30, 2002·Biochemical Pharmacology·James M JamisonJ L Summers
Mar 1, 1979·Journal of Toxicology and Environmental Health·Z Hruban
Jun 15, 2004·Life Sciences·Henryk S TaperPedro Buc Calderon
Feb 1, 1982·Toxicologic Pathology·P BannaschHeide Zerban
Jan 1, 1978·Acta Radiologica: Oncology, Radiation, Physics, Biology·P Frederiksen, P Thommesen
May 5, 2011·Nutrition and Cancer·Ana Catarina MamedeMaria Filomena Botelho

Related Concepts

Neoplastic Cell Transformation
Alkaline DNase
DNA, Neoplasm
Liver Carcinoma
Liver Glycogen
Malignant Neoplasm of Liver
Neoplasms, Experimental

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