PMID: 38281Jan 1, 1978

Histochemical investigation of some mitochondrial and microsomal enzymes in the kidneys of rabbits immunized with type B botulinus anatoxin

Journal of hygiene, epidemiology, microbiology, and immunology
I E Gendler, G E Sinel'nikov

Abstract

Immunization of rabbits with botulinus anatoxin containing a number of proteins of bacterial origin causes a statistically significant increase in the activity of succinate dehydrogenase, NAD diaphorase and NADP diaphorase as early as after 24 hours. After 5-7 days, the activity of all mitochondrial enzymes drops below the control level and returns to normal by the 14th day. The activity of glucose 6-phosphatase decreases significantly already 24 hours after immunization and returns to normal by the end of the 7th day. The mechanism of excretion of foreign protein in the kidneys of immunized animals is discussed.

Related Concepts

Variolation
Glucosephosphatase
Succinate Dehydrogenase
Microsomes
Anatoxin Toxoids
Kidney
Antigens, Bacterial
Mitochondria
NADP
Cytochemistry

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