Histochemical localization of acidic glycosaminoglycans in normal human placentae

Placenta
L WassermanD Allalouf

Abstract

First-trimester and term placentae were studied histochemically with alcian blue stain before and after specific enzyme treatments. A specific deposition of glycosaminoglycans was detected in the villous stroma, fetal blood vessels and on the surface of the syncytiotrophoblast, the latter being discontinuous and of variable thickness. Treatments of sections with hyaluronidases from Streptomyces and from bovine testes and with chondroitinase ABC indicated the presence of (1) chondroitin sulphates and hyaluronic acid mainly in the stroma; (2) heparan sulphate and dermatan sulphate associated with villous fetal blood vessels and the intervillous surface of the syncytiotrophoblast. It is suggested that the location of individual glycosaminoglycans could be related to their functions with regard to the maintenance of the structural integrity of the placenta by preventing its compression and to their involvement in blood anticoagulation and in lipid metabolism.

References

Jan 1, 1978·Annual Review of Biochemistry·U Lindahl, M Höök
Mar 1, 1975·Analytical Biochemistry·Y Hatae, A Makita
Aug 1, 1967·The Journal of Obstetrics and Gynaecology of the British Commonwealth·D LovellR C Curran
Jul 17, 1964·Histochemie. Histochemistry. Histochimie·G QuintarelliM C Dellovo
Jan 1, 1982·Gynecologic and Obstetric Investigation·I G GorodeskiC M Bahari
Dec 1, 1980·American Journal of Obstetrics and Gynecology·L WassermanD Allalouf

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