PMID: 43724Jan 1, 1979

Histochemical studies of some hepatic enzyme activities in rat during extrahepatic common bile duct obstruction

Basic and Applied Histochemistry
T RendaE Salvi


Studies on some enzyme activities as measured histochemically in the ligated common bile duct rat liver are reported. They show principally: an increased GGT reaction in the neoductular cells; a diffusion of the LAP reaction to the neoductuli; an immediate increase and diffusion of the alkaline phosphatase reaction; an increase of G-6-PA and AMPA reactions; an increase, during the first week, of the Phyla activity and a contemporary decrease of the UDPG-GS reaction. No significant changes have been observed in other enzyme activities. By means of some dehydrogenase reactions, morphological evidence that the hepatocytes may be involved in neoductular cells formation was obtained.

Related Concepts

Alkaline Phosphatase
Cholestasis, Extrahepatic
Common Bile Duct Diseases
Gamma-glutamyl transferase
Synthase I
Methoxyleucine Aminopeptidase

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