Aug 15, 1989

Histochemical studies of transepidermal elimination of nevus cells in nevus cell nevi of the corium

Zeitschrift für Hautkrankheiten
U WollinaC Hipler

Abstract

Dermal nevocytic nevi (NN) were histochemically studied with the help of FITC-conjugated lectins as well as antisera against keratin and plasminogen activators of the urokinase type. 3 out of 18 NN showed interpenetrating nevus cells in atrophic parts of the epidermis. These cells revealed strong lectin reactivity both with Con A (cytoplasmatic binding) and WGA/RCA II (membraneous binding). In addition we found membraneous reaction with anti-urokinase, whereas there was no anti-keratin staining. Our findings suggest active transepidermal elimination of nevus cells in dermal nevocytic nevi.

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Mentioned in this Paper

Malignant Neoplasm of Skin
PLAU gene
Immunofluorescence Assay
Nevus
Keratinocyte
Dermis
Keratin
Immune Sera
Cytokeratin
Plasminogen Activator

About this Paper

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