PMID: 8592797Nov 1, 1995Paper

Histochemical study of cutaneous mucins in hypothyroid dogs

Veterinary Pathology
S DoligerJ P Magnol

Abstract

A dermal mucinosis, visualized as dermal alcianophilic material, is occasionally present in canine hypothyroidism (myxedema). Various histochemical reactions (alcian blue/periodic acid-Schiff [PAS], alcian blue at pH 2.6, alcian blue at pH 1.0, critical electrolytical concentrations with and without dimethylsulfoxide, differential hydrolysis by hyaluronidases) were performed on skin biopsies from six dogs (four females and two males ranging from 8 to 13 years) affected by hypothyroidism, all of them presenting dermal mucinosis in hematoxylin and eosin-stained sections. In these dogs, the only polysaccharidic compound involved in the dermal mucinosis was hyaluronic acid. In this study, hyaluronic acid dermal deposits of hypothyroid dogs were significantly different from those of controls in subepidermal connective tissue and loose reticular connective tissue but not in periadnexal zones. We recommend the combined alcian blue/PAS reaction as a routine technique to assess dermal mucinosis in hypothyroid dogs.

References

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Citations

Feb 7, 2014·Pakistan Journal of Biological Sciences : PJBS·Ahad RaziMohamad Goldust
Jul 17, 2014·Journal of the American Animal Hospital Association·Shinichi UtsugiG Diane Shelton
Jul 10, 2007·The Veterinary Clinics of North America. Small Animal Practice·J Catharine Scott-Moncrieff
Sep 26, 2001·The Veterinary Clinics of North America. Small Animal Practice·D L Panciera
Jan 30, 2010·Veterinary Pathology·T MüntenerM Welle
Jun 20, 2014·Veterinary Pathology·C PalmieriH L Shivaprasad
Jul 6, 2012·Clinical Microbiology Reviews·Fernando SimónJose Alberto Montoya-Alonso

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