Histochemical study of strain L fibroblasts exposed to endotoxin. The effect on cellular organelles

Journal of Periodontology
R M LucasJ J Aleo

Abstract

Endotoxin was found to be nonselective in its cytotoxicity of cellular organelles. All organelles studied displayed some degree of alteration which became more severe as the concentration of endotoxin was increased. The data suggest that the metabolism of the cell may be compromised at concentrations of endotoxin which do not affect cell viability. The problem involved in attempting to determine the actual concentration of endotoxin at the interface between the culture medium and the cell monolayer, in vitro, and the corresponding situation, in vivo, are also discussed.

References

Mar 1, 1970·Journal of Periodontology·L A NortonR R Moore
Jan 1, 1966·Journal of Periodontal Research·S B JensenJ S Jensen
Jul 1, 1973·The Journal of Infectious Diseases·J W Shands
Apr 1, 1973·Archives of Oral Biology·M E Neiders, L Weiss
May 15, 1970·Science·E HausmannW A Miller
Nov 1, 1971·Infection and Immunity·C BonaA Lamensans
Jan 1, 1971·Scandinavian Journal of Dental Research·K A SelvigT Kristoffersen
Dec 1, 1956·Experimental Cell Research·J P CHANG
Jan 1, 1963·Acta Pathologica Et Microbiologica Scandinavica·S BERGMAN, S B NILSSON
Nov 1, 1964·Archives of Oral Biology·A A RIZZO, S E MERGENHAGEN

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Citations

Sep 1, 1986·Journal of Clinical Periodontology·O FardalE Freeman
May 1, 1980·Journal of Periodontology·M R Wirthlin, E B Hancock
Dec 1, 1980·Journal of Periodontology·L J AdelsonR G Caffesse
Nov 1, 1984·Journal of Periodontology·J J AleoA Subramoniam
Dec 16, 1998·Journal of Periodontology·T FujiiY Kowashi
Jun 1, 1988·Journal of Periodontology·L Checchi, G A Pelliccioni
Aug 1, 1996·Journal of Periodontal Research·M WilsonB Henderson
Jan 1, 1984·Infection and Immunity·A ProgulskeS C Holt

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