PMID: 40926Sep 1, 1979

Histochemical study on the pathogenesis of chlorocyclizine-induced pulmonary lipidosis

Histochemistry
E Gaton, M Wolman

Abstract

Male rats were fed a diet containing chlorocyclizine in high concentrations for about 3 weeks. They lost weight and showed respiratory distress. The lungs contained clusters of foam cells in the alveoli. Acid esterase staining revealed reduction of activity in alveolar cells presumed to be granular pneumocytes and absence of activity in the foam cells. The lipid showed in the foam cells could not be stained with Sudan dyes, except at high temperature, and was not stained by phospholipid and cholesterol procedures. This indicated that the stored lipids are probably solid at room temperature, consisting of saturated triglycerides and/or phospholipids. It is suggested that the lipid originated in the granular pneumocytes. The drug might have deranged the esterase-phospholipase activity in these cells and in the macrophages.

References

Jan 31, 1977·Archives of Dermatological Research·M WolmanM Michowitz
Sep 1, 1973·Toxicology and Applied Pharmacology·Z HrubanI Aschenbrenner
Sep 1, 1974·Atherosclerosis·M Wolman
Jul 1, 1972·The Journal of Clinical Investigation·H R Sloan, D S Fredrickson
Dec 2, 1965·Biochimica Et Biophysica Acta·G H de HaasJ Roger
Jan 1, 1959·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·C L MARKERT, R L HUNTER

Citations

Nov 29, 1983·Biochimica Et Biophysica Acta·N SternM Wolman
Jan 1, 1981·Toxicology·M J Reasor
Apr 1, 1984·Environmental Health Perspectives·Z Hruban
Apr 1, 1985·Perceptual and Motor Skills·H B Gibson
Mar 1, 1983·The British Journal of Psychiatry : the Journal of Mental Science·M Koukkou, D Lehmann
Dec 1, 1982·Perceptual and Motor Skills·S Starker

Related Concepts

Esterases
Foam Cells
Lipids
Lipoidosis
Lung Diseases
Macrophage
Piperazines
Pulmonary Alveolar Structure

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