PMID: 7335146Jan 1, 1981Paper

Histocompatibility antigens (HLA) and patterns of cognitive loss in dementia of the Alzheimer type

Neurobiology of Aging
D CohenR L Walford

Abstract

Recent data suggest that a proportion of patients with primary neuronal degeneration of the Alzheimer type have the HLA-B7 antigen. However, the possibility that other differences might exist between patients with and without the marker has not been examined. We tested a range of cognitive skills in Alzheimer patients with and without the HLA-B7 to examine whether those individuals with the HLA marker would exhibit a profile of cognitive loss different from those without it. Our results indicate that patients with HLA-B7 antigens had selective attentional scores that were significantly lower than Alzheimer patients without the antigen. Neither group was significantly different in either memory capacity or retrieval from short-term and long-term memory. The data support the hypothesis that there may be more than one disorder in what is now referred to as dementia of the Alzheimer type.

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Jan 1, 1980·The British Journal of Psychiatry : the Journal of Mental Science·C Eisdorfer, D Cohen

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Citations

Apr 1, 1986·Archives of Gerontology and Geriatrics·H EndoF Kuzuya
Mar 31, 2004·Experimental Gerontology·Giuseppina CandoreCalogero Caruso
Feb 13, 2001·Neurobiology of Aging·D J LehmannA D Smith
Feb 21, 2013·European Journal of Human Genetics : EJHG·André MégarbanéDavid Piquemal
Mar 1, 1986·Environmental Health Perspectives·P O Ganrot
Jan 1, 1982·Annals of the New York Academy of Sciences·R L Walford
Sep 10, 2005·Care Management Journals : Journal of Case Management ; the Journal of Long Term Home Health Care·Sharon Fish Mooney
Dec 5, 2013·Physiological Reports·Majid Moshtagh-KhorasaniVincent Torre

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