PMID: 6982903Oct 1, 1982Paper

Histocompatibility antigens in progressive systemic sclerosis (PSS; scleroderma)

Journal of Clinical Immunology
C J LynchB S Rabin

Abstract

Patients with progressive systemic sclerosis (PSS; scleroderma) were typed for the HLA-A, -B, and -DR antigens. No significant differences in the frequencies of any HLA-A or -B antigen were found. In the subgroup of patients with PSS and diffuse scleroderma (PSS-DS), the frequency of Bw35 was increased (0.30 vs 0.17 in controls; p less than 0.005, corrected P greater than 0.2). Although patients with PSS-DS also had an increased frequency of DR1 antigen (0.27 vs 0.12 in local controls; P less than 0.005, corrected P less than 0.05), no association between Bw35 and DR1 antigens could be detected. We found no increase in the frequencies of the DR3 or DR5 antigens in patients with PSS. However, in a subset of PSS patients with pulmonary fibrosis, an increase in DR3 and a decrease in DR4 antigens (P less than 0.005) were observed. Serum antibodies to centromere occurred more frequently in DR1-positive than DR/-negative patients (0.46 vs 0.18; P less than 0.005). This study of a large number of patients with PSS failed to confirm previously reported associations of PSS with the HLA-B8/DR3 haplotype of HLA-DR5 antigen.

References

Oct 21, 1976·The New England Journal of Medicine·F H Bach, J J van Rood
Oct 14, 1976·The New England Journal of Medicine·F H Bach, J J Rood
Apr 20, 1978·The New England Journal of Medicine·P Stastny
Feb 1, 1977·Seminars in Arthritis and Rheumatism·J C Woodrow
Oct 1, 1979·Archives of Dermatological Research·M GiordanoR De Biasi
Oct 1, 1979·Tissue Antigens·A MájskýZ Stáva
Nov 10, 1978·Archives of Dermatological Research·J FreudenbergG W Korting
Nov 1, 1977·Annals of Internal Medicine·J F CipolettiG P Rodnan
Jan 1, 1972·The American Journal of Medicine·H O McDevitt, W F Bodmer
Jan 1, 1981·Immunological Communications·A G DiBartolomeoG P Rodnan
Jun 1, 1981·Arthritis and Rheumatism·B F GermainF B Vasey
Jun 1, 1981·Arthritis and Rheumatism·D D GladmanH Mervert

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Citations

Aug 15, 2001·Arthritis and Rheumatism·I MarieH Courtois
Mar 1, 1992·Clinical and Experimental Dermatology·C BlackK Welsh
Oct 1, 1986·Annals of the Rheumatic Diseases·P J MaddisonK I Welsh
Nov 1, 1991·Annals of the Rheumatic Diseases·A J Silman
Nov 1, 1991·Annals of the Rheumatic Diseases·D Briggs, K I Welsh
Jun 1, 1985·Journal of the American Academy of Dermatology·P L MyskowskiB Safai
Apr 1, 1994·Clinics in Dermatology·T A Medsger
Jan 1, 1985·The British Journal of Dermatology·K TakeharaY Ishibashi
Jun 1, 1988·The American Journal of Medicine·A R McGregorH R Maricq
Oct 1, 1992·Clinics in Dermatology·D Y PorgesA Gibofsky
Jan 1, 1995·International Reviews of Immunology·F C Arnett
Jan 1, 1986·Arthritis and Rheumatism·D C TrostleT A Medsger
May 1, 1990·Arthritis and Rheumatism·E GenthP W Hartl
Jul 1, 1994·Clinics in Dermatology·C M Black, K I Welsh
Mar 1, 1988·Journal of the American Academy of Dermatology·T Krieg, M Meurer
Apr 1, 1993·Journal of the American Academy of Dermatology·M I Perez, S R Kohn

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