Oct 1, 1977

Histocompatibility determinants in Israeli Jewish patients with multiple sclerosis

Tissue Antigens
C BrautbarL Lamm

Abstract

The distribution of 24 HLA antigens of the A and B loci was investigated in 197 Israeli Jewish patients with multiple sclerosis (MS) from various Jewish ethnic origins including central and eastern Europe, countries bordering the Mediterranean, the Middle East and from native-born Israelis. The results were compared with the HLA antigen frequencies in a control sample of 455 unrelated individuals representing the general Jewish population. The frequency of HLA-Bw40 among all MS patients (15%) was significantly greater (P less than 0.001) than among the controls (7%). In contrast to the findings in MS patients from other populations, there was no increased frequency of A3 and B7 and Dw2 was present in only one out of 28 patients. The study showed a similar distribution of HLA-A and -B locus antigens, especially of Bw40, in Jews of diverse ethnic origins represented in the control group.

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Mentioned in this Paper

Antigenic Specificity
HLA Antigens
Haploid Cell
Human Leukocyte Antigen (HLA) A Antigen Typing (Procedure)
Antigens
MS gene
Locus
HLA-A Antigens
Multiple Sclerosis, Acute Fulminating
Multiple Sclerosis

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