PMID: 6396831Jan 1, 1984Paper

Histogenesis of colon cancer in experimental animals

Scandinavian Journal of Gastroenterology. Supplement
W W Chang

Abstract

Following the introduction of colon-specific carcinogens, the mode of formation and evolution of colon cancer has been investigated in experimental animals. These carcinogens are cytotoxic to epithelial cells in colonic crypts and induce a series of non-specific acute and chronic changes including cryptal hyperplasia when administered repeatedly. During such processes, a number of neoplastically transformed cells may appear in many crypts. Only when they occur at the base of or form an outpocketing pouch in a crypt, do they appear to succeed in repopulating the given crypt to form a dysplastic crypt, from which an early neoplastic lesion develops usually in the upper part of the mucosa. The neoplastic lesion thus formed grows by various mechanisms, depending on its intrinsic properties of unceasing proliferative activity of neoplastic cells and interaction with the microenvironment: (a) by elongation and tortuosity of neoplastic glands, (b) by evagination of the glandular epithelial lining, with the formation of septa to dichotomise the glands to increase the number of neoplastic glands or with formation of incomplete septa or villi to expand the surface area of the neoplasm, and (c) by invagination and outpocketing pouch forma...Continue Reading

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