Thirty-one dog thyroid tumours and 28 spontaneous rat thyroid tumours were studied histologically and the findings compared with those of a study of 67 cases of medullary carcinoma of the human thyroid. Five of the dog tumours and 24 of the rat tumours were considered to belong to the same group of tumours as medullary carcinoma, a group characterized by solid sheets or lobules of uniform cells with granular cytoplasm and without papillary or follicular differentiation. In the rat tumours it was shown that the cell of origin was the parafollicular cell and not the thyroid follicle epithelial cell. It is suggested that medullary carcinoma is also derived from a parafollicular cell and that this origin would resolve the discrepancy between the relatively good prognosis and the apparently undifferentiated structure of this tumour. It is also concluded that the whole spectrum of clinical and pathological features of medullary carcinoma makes more sense if it is considered as a parafollicular cell tumour.
The effect of radioactive iodine alone and in combination with methylthiouracil upon tumour production in the rat's thyroid gland
THYROID HYPOCALCEMIC PRINCIPLE AND RECURRENT LARYNGEAL NERVE INJURY AS FACTORS AFFECTING THE RESPONSE TO PARATHYROIDECTOMY IN RATS
Medullary cancer of the thyroid gland and its possible relations to carcinoids. An ultrastructural study
Production of gastrin releasing peptide by medullary carcinoma of the thyroid. An immunohistochemical study
Immunohistochemical study of medullary thyroid carcinoma: relationship of clinical features to prognostic factors in 36 patients
Alterations of the mitotic index of C cells and follicular cells of the rat thyroid during the circadian rhythm and after exposure to cold
Provocative testing for occult medullary carcinoma of the thyroid: findings in seven children with multiple endocrine neoplasia type IIa
Syndrome of bilateral pheochromocytoma, medullary thyroid carcinoma and multiple neuromas. A possible regulatory defect in the differentiation of chromaffin tissue
Case records of the Massachusetts General Hospital. Weekly clinicopatological exercises. Case 35-1973
High level of a nerve growth factor in the serum of a patient with medullary carcinoma of the thyroid gland
Peroxidase activity in benign nodular lesions and carcinoma in the rat thyroid induced by N-nitrosobis (2-hydroxypropyl) amine and phenobarbital
A comparison of medullary thyroid carcinoma and thyroid adenocarcinoma in dogs: a retrospective study of 38 cases
Light-electron microscopic and cytochemical studies on the morphogenesis of familial medullary thyroid carcinoma
Comparative ultrastructure of thyroid, tongue and eyelid lesions in the neuroma phenotype of medullary carcinoma of the thyroid: association of amyloid with fibroblasts in thyroid tumor and in mucosal neuromas
Multiple endocrine cell types in thyroid medullary carcinoma. Evidence for calcitonin, somatostatin, ACTH, 5HT and small granule cells
Prognostic significance of disseminated tumor cells in the connective tissue of patients with medullary thyroid carcinoma
Identification of a novel 'aggregation-prone'/'amyloidogenic determinant' peptide in the sequence of the highly amyloidogenic human calcitonin
Diversity of mutations in the RET proto-oncogene and its oncogenic mechanism in medullary thyroid cancer
Tissue levels of monoamines and monamine metabolizing enzymes in medullary carcinoma and other thyroid diseases
Medullary thyroid carcinoma--an uncommon cause of thyroid nodules but an important cause of thyroid neoplasms
Chromogranin A immunoreactivity compared with argyrophilia, calcitonin immunoreactivity, and amyloid as tumour markers in the histopathological diagnosis of medullary (C-cell) thyroid carcinoma
The oncogenic activity of RET point mutants for follicular thyroid cells may account for the occurrence of papillary thyroid carcinoma in patients affected by familial medullary thyroid carcinoma
Chromosomal aberrations in thyroid follicular-cell neoplasia: in the search of novel oncogenes and tumour suppressor genes
Cutaneous metastasis of medullary carcinoma thyroid masquerading as subcutaneous nodules anterior chest and mandibular region
Genetic testing in endocrinology: lessons learned from experience with multiple endocrine neoplasia type 2 (MEN2)
Thyroglobulin in medullary thyroid carcinoma: immunohistochemical study with polyclonal and monoclonal antibodies
Thyrotrophin releasing hormone induced calcitonin secretion in patients with medullary carcinoma of the thyroid
Cholecystokinin-B/Gastrin receptor-targeting peptides for staging and therapy of medullary thyroid cancer and other cholecystokinin-B receptor-expressing malignancies
Clinical outcomes of patients with hypercalcitoninemia after initial treatment for medullary thyroid cancer and postoperative serum calcitonin cutoffs for predicting structural recurrence
Thyroid C cells and their pathology: Part 1: normal C cells, - C cell hyperplasia, - precursor of familial medullary thyroid carcinoma
Molecular and other novel advances in treatment of metastatic epithelial and medullary thyroid cancers
Hypervascularity is more frequent in medullary thyroid carcinoma: Compared with papillary thyroid carcinoma
Incidence of sporadic and familial medullary thyroid carcinoma in Sweden 1959 through 1981. A nationwide study in 126 patients. Swedish MCT Study Group
Gross, histologic, cytochemical, and immunocytochemical study of medullary thyroid carcinoma in sixteen dogs
Ultrastructure of canine carotid body and aortic body tumors. Comparison with tissues of thyroid and parathyroid origin
Cholecystokinin-B (CCK-B)/gastrin receptor targeting peptides for staging and therapy of medullary thyroid cancer and other CCK-B receptor expressing malignancies
Immunohistochemistry of medullary thyroid carcinoma and C-cell hyperplasia by an affinity-purified anti-human calcitonin antiserum
Microfollicular thyroid carcinoma with amyloid rich stroma, resembling the medullary carcinoma of the thyroid (MCT)
Clinical characteristics in sporadic and familial medullary thyroid carcinoma. A nationwide study of 249 patients in Sweden from 1959 through 1981
Histologic and ultracytochemical studies on thyroid medullary carcinoma. Diagnostic significance of argyrophil secretory granules
C-cell hyperplasia developing in residual thyroid following resection for sporadic medullary carcinoma
Nonparallel patterns of calcitonin and carcinoembryonic antigen levels in the follow-up of medullary thyroid carcinoma
Familial medullary thyroid carcinoma, pheochromocytoma, and parathyroid adenoma (Sipple's syndrome). Study of a kindred
Thyroid carcinoma and Cushing's syndrome. A report of two cases with a review of the common features of the "non-endocrine" tumours associated with Cushing's syndrome
Ultrasonographic findings of medullary thyroid carcinoma: a comparison with papillary thyroid carcinoma
C and APUD cells and endocrine tumours. Pearse's laboratory in the years 1965-1969: a personal recollection
Grading of medullary thyroid carcinoma on the basis of tumor necrosis and high mitotic rate is an independent predictor of poor outcome
18F-FDG PET, somatostatin receptor scintigraphy, and CT in metastatic medullary thyroid carcinoma: a clinical study and an analysis of the literature
Letter to the Editor: Comment on Therapeutic Effectiveness of Screening for Multiple Endocrine Neoplasia Type 2A by Machens A. and Dralle H
Clinical review 167: Procalcitonin and the calcitonin gene family of peptides in inflammation, infection, and sepsis: a journey from calcitonin back to its precursors
Update on the Treatment of Medullary Thyroid Carcinoma in Patients with Multiple Endocrine Neoplasia Type 2
Hyperplastic and neoplastic changes in ultimobranchial remnants and in parafollicular (C) cells in bulls: a histologic and immunohistochemical study
Medullary Thyroid Cancer: Clinical Characteristics and New Insights into Therapeutic Strategies Targeting Tyrosine Kinases
Naturally occurring parafollicular cell carcinoma of the thyroid in dogs. A histological and ultrastructural study
Pathogenesis of C-cell neoplasia in thyroid gland. C-cell proliferation in a case of chronic hypercalcaemia
Argentaffin cells in human thyroid and parathyroid and their relationship to c-cells and medullary carcinoma
Genomics and Epigenomics of Medullary Thyroid Carcinoma: From Sporadic Disease to Familial Manifestations.
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