PMID: 5948665Mar 1, 1966Paper

Histogenesis of medullary carcinoma of the thyroid

Journal of Clinical Pathology
E D Williams

Abstract

Thirty-one dog thyroid tumours and 28 spontaneous rat thyroid tumours were studied histologically and the findings compared with those of a study of 67 cases of medullary carcinoma of the human thyroid. Five of the dog tumours and 24 of the rat tumours were considered to belong to the same group of tumours as medullary carcinoma, a group characterized by solid sheets or lobules of uniform cells with granular cytoplasm and without papillary or follicular differentiation. In the rat tumours it was shown that the cell of origin was the parafollicular cell and not the thyroid follicle epithelial cell. It is suggested that medullary carcinoma is also derived from a parafollicular cell and that this origin would resolve the discrepancy between the relatively good prognosis and the apparently undifferentiated structure of this tumour. It is also concluded that the whole spectrum of clinical and pathological features of medullary carcinoma makes more sense if it is considered as a parafollicular cell tumour.

Citations

Oct 31, 1968·Helvetica Chimica Acta·B RinikerI MacIntyre
Jul 1, 1995·Journal of Surgical Oncology·L A MarzanoL Zarrilli
Jan 1, 1972·Virchows Archiv. A: Pathology. Pathologische Anatomie·E HorvathR C Ross
Jan 1, 1983·Virchows Archiv. A, Pathological Anatomy and Histopathology·T KameyaN Yanaihara
Jan 1, 1987·Virchows Archiv. A, Pathological Anatomy and Histopathology·K KakudoK Watanabe
Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·R HolmJ V Johannessen
Aug 1, 1984·World Journal of Surgery·N A SamaanR C Hickey
Oct 1, 1986·World Journal of Surgery·G RiccabonaK W Schmid
Dec 31, 1973·Zeitschrift für Zellforschung und mikroskopische Anatomie·B Kaissling, O Bucher
Sep 1, 1974·The Japanese Journal of Surgery·T ObaraM Fukumitsu
Nov 1, 1989·The Japanese Journal of Surgery·R A Decker, Samuel A Wells
Jun 23, 2006·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Isabel Peixoto CallejoJorge Rosa Santos
Jan 1, 1977·Acta histochemica·M BeskidT Tolloczko
Mar 1, 1979·Clinics in Endocrinology and Metabolism·E D Williams
Aug 14, 2001·Molecular and Cellular Endocrinology·G MantovaniA Spada
Mar 7, 1968·The New England Journal of Medicine·J S Meyer, W Abdel-Bari
Aug 30, 1973·The New England Journal of Medicine·H J WolfeA H Tashjian
Oct 17, 2003·The New England Journal of Medicine·Gilbert J Cote, Robert F Gagel
Apr 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·K E Melvin, A H Tashjian
May 28, 2009·Thyroid : Official Journal of the American Thyroid Association·American Thyroid Association Guidelines Task ForceSamuel A Wells
Sep 1, 1967·Annals of Surgery·M A BlockB E Brush
Jan 7, 2009·Current Opinion in Oncology·Sanziana RomanJulie Ann Sosa
Sep 1, 1990·Clinical Endocrinology·J BoultwoodE D Williams
Mar 1, 1990·Histopathology·H BeermanR W Veldhuizen
Aug 1, 1973·Acta Pathologica Japonica·Y Yamaoka
Sep 1, 1977·Acta Pathologica Japonica·K KakudoS Katayama
Mar 1, 1982·Acta Pathologica Japonica·K KakudoF Matsuzuka
Sep 1, 1982·Acta Pathologica Japonica·K KakudoA Kawaoi
Jun 1, 1989·Acta Pathologica Japonica·N LertprasertsukeM Kubota
Dec 1, 1970·Journal of Clinical Pathology·P W Leedham, D J Pollock
Feb 1, 1991·Journal of Clinical Pathology·M HigashiyamaS Takai
Feb 1, 1993·Journal of Clinical Pathology·H R Harach, U Bergholm
Feb 1, 1981·Postgraduate Medical Journal·J C StevensonB M Stevenson
Jun 21, 2011·Journal of Thyroid Research·Karen GómezCamilo Jimenez
Nov 8, 2012·Future Oncology·Concetto RegalbutoVincenzo Pezzino
Oct 27, 1977·Virchows Archiv. A, Pathological Anatomy and Histology·W SchürchM Verdy
May 13, 1972·British Medical Journal
Jan 1, 1987·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·A NakamuraK Watanabe
Dec 19, 2015·Critical Reviews in Clinical Laboratory Sciences·Mehdi HedayatiFarinaz Afsari
Jul 1, 1981·The American Journal of the Medical Sciences·J M Feldman, S A Wells
May 16, 2013·Current Problems in Surgery·Judy JinChristopher R McHenry
Dec 8, 2009·Molecular and Cellular Endocrinology·Horst ZitzelsbergerKristian Unger
May 1, 1990·Journal of Comparative Pathology·J Kaspareit-RittinghausenB Nitsche
Dec 8, 2007·Clinical Endocrinology·Andreas Machens, Henning Dralle
Jun 26, 2013·CA: a Cancer Journal for Clinicians·David F Schneider, Herbert Chen
May 12, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Camilo Jimenez, Robert F Gagel
Nov 1, 1968·The American Journal of Medicine·H W WahnerF Aljure
Nov 7, 1999·The American Journal of Pathology·X Matias-Guiu
Sep 11, 1990·Journal of Pediatric Surgery·R A DeckerSamuel A Wells
Mar 1, 1990·Trends in Endocrinology and Metabolism : TEM·S B Baylin
May 1, 1985·Current Problems in Surgery·W G Cance, Samuel A Wells
Jul 1, 2005·Annales d'endocrinologie·A FalchettiM L Brandi
Aug 1, 1988·Journal of Pediatric Surgery·J G DesjardinsP Simard
Dec 1, 1986·Clinical Endocrinology·S SchifterH H Hansen
Aug 1, 1986·Histopathology·N W WilsonE Heyderman
Jul 1, 1981·Clinics in Endocrinology and Metabolism·H J Wolfe, R A Delellis
Aug 20, 2015·Endocrine-related Cancer·Margarida M MouraValeriano Leite
Mar 27, 2015·Thyroid : Official Journal of the American Thyroid Association·Samuel A WellsAmerican Thyroid Association Guidelines Task Force on Medullary Thyroid Carcinoma
Sep 1, 1978·Veterinary Pathology·A K PatnaikS K Liu
Sep 1, 1991·Veterinary Pathology·J W CrissmanI Evangelista-Sobel
Sep 1, 1991·Veterinary Pathology·B LeblancC Jobit
Jan 1, 1972·Veterinary Pathology·G S DillG D Whitney
Feb 1, 1971·Clinical Pediatrics·G S Sturtz, R B Brown
Jun 24, 2017·Archives of Pathology & Laboratory Medicine·Theresa Scognamiglio
Jul 21, 2004·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Henry T LynchJane F Lynch
Apr 1, 1971·Cancer·S H Dikman, C Toker
Nov 1, 1979·Cancer·Gianni Bussolati, G Monga
Feb 1, 1968·Cancer·S N Huang, W A McLeish
May 15, 1990·Cancer·H Galera-DavidsonM Bibbo
Jan 1, 1974·Annals of the New York Academy of Sciences·K E Melvin
Apr 1, 1975·The British Journal of Surgery·J M BeaugieM H Lloyd
Sep 1, 1970·The British Journal of Surgery·F T McDermott, J A Hart
May 1, 1976·The British Journal of Surgery·W E Roediger
Jan 1, 1991·Cytopathology : Official Journal of the British Society for Clinical Cytology·M E MendonçaJ Soares
Mar 10, 2009·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Sung-Hun KimChan-Kwon Jung
Apr 21, 2009·Endocrine Pathology·Meghan Sara Adams, Marianne Bronner-Fraser
Feb 1, 1984·The Journal of Pathology·E Cotchin
Feb 1, 1979·The Journal of Pathology·B A Fraser, J W Duckworth
Jul 1, 1988·The Journal of Pathology·H R Harach
Jul 1, 1988·Histopathology·I Martin-LacaveH Galera-Davidson
Jan 1, 1972·Virchows Archiv. A: Pathology. Pathologische Anatomie·K AtermanM Lee
Jan 1, 1985·Ultrastructural Pathology·R GolouhV Eusebi
Jan 1, 1985·Ultrastructural Pathology·R HolmJ V Johannessen
Sep 23, 2014·Annals of Surgical Oncology·Kathryn J RowlandJeffrey F Moley
Jan 13, 2005·The American Journal of Surgical Pathology·J Aidan Carney
Apr 22, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Bayan AlzumailiRonald A Ghossein
Aug 24, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity·Theresa Tran, Andrew G Gianoukakis
Oct 13, 2016·The Journal of Clinical Endocrinology and Metabolism·Giovanni TalliniRonald A Ghossein
Oct 7, 2015·The Journal of Clinical Endocrinology and Metabolism·Hannah Linane, Aoife M Egan Galway
Sep 28, 2006·Annals of the Royal College of Surgeons of England·Mahir Al-Rawi, Malcolm H Wheeler
Apr 17, 2020·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Maran IlanchezhianJaydira Del Rivero
Jan 1, 1975·Acta Medica Scandinavica·N SöderströmM Akerman
Jan 1, 1976·Veterinary Pathology·J Vitovec
Mar 1, 1975·Cancer·G C ChongL H Woolner
Nov 1, 1988·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·S J PearlmanH F Biller
Nov 1, 1968·Australasian Annals of Medicine·A SlavotinekR Head
May 1, 1980·Veterinary Pathology·G G LongH Heath
Apr 3, 1998·Annals of Surgical Oncology·P R FuchshuberD P Shedd
Feb 18, 2016·World Journal of Clinical Cases·Evangelos P MisiakosAnastasios Machairas
Jan 25, 2019·Visceral Medicine·Theresia Weber
Jul 1, 1979·Acta Pathologica Japonica·K KakudoH Kitamura
May 31, 2019·In Vitro Cellular & Developmental Biology. Animal·Kumiko OkanoHidehiro Hirao
Mar 20, 2020·Endocrine·Dillwyn Williams
Feb 1, 1970·Australasian Annals of Medicine·C I JohnstonJ Riddell
Dec 1, 1983·Ultrastructural Pathology·J V JohannessenI O Brennhovd
Jan 1, 1966·Acta Pathologica Et Microbiologica Scandinavica·O Ljungberg
Jan 1, 1972·Acta Pathologica Et Microbiologica Scandinavica. Section A, Pathology·O Ljungberg, J F Dymling
Apr 1, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Marjan Zarif YeganehMehdi Hedayati
May 11, 2018·Endocrine Pathology·Zubair BalochSylvia L Asa
Aug 14, 2018·Nuclear Medicine and Molecular Imaging·Daiki Kayano, Seigo Kinuya
May 23, 2000·Diagnostic Cytopathology·K PapaparaskevaM Droese
Jan 1, 1972·Acta Pathologica Et Microbiologica Scandinavica. Section A, Pathology·O Ljungberg
Oct 23, 2020·Indian Journal of Endocrinology and Metabolism·P R ManjunathPrem Narayanan
Mar 10, 2021·Endocrine Pathology·Virginia A Livolsi

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