Histogram Analysis of Diffusion Kurtosis Magnetic Resonance Imaging for Diagnosis of Hepatic Fibrosis

Korean Journal of Radiology : Official Journal of the Korean Radiological Society
Ruo-Fan ShengMeng-Su Zeng

Abstract

To investigate the diagnostic value of diffusion kurtosis imaging (DKI) histogram analysis in hepatic fibrosis staging. Thirty-six rats were divided into carbon tetrachloride-induced fibrosis groups (6 rats per group for 2, 4, 6, and 8 weeks) and a control group (n = 12). MRI was performed using a 3T scanner. Histograms of DKI were obtained for corrected apparent diffusion (D), kurtosis (K) and apparent diffusion coefficient (ADC). Mean, median, skewness, kurtosis and 25th and 75th percentiles were generated and compared according to the fibrosis stage and inflammatory activity. A total of 35 rats were included, and 12, 5, 5, 6, and 7 rats were diagnosed as F0-F4. The mean, median, 25th and 75th percentiles, kurtosis of D map, median, 25th percentile, skewness of K map, and 75th percentile of ADC map demonstrated significant correlation with fibrosis stage (r = -0.767 to 0.339, p < 0.001 to p = 0.039). The fibrosis score was the independent variable associated with histogram parameters compared with inflammatory activity grade (p < 0.001 to p = 0.041), except the median of K map (p = 0.185). Areas under the receiver operating characteristic curve of D were larger than K and ADC maps in fibrosis staging, although no significant ...Continue Reading

References

Aug 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P Bedossa, T Poynard
Dec 20, 2002·AJR. American Journal of Roentgenology·Stephen J Karlik
May 21, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jens H JensenKyle Kaczynski
Jun 27, 2008·Journal of Magnetic Resonance Imaging : JMRI·Bachir TaouliValérie Vilgrain
Dec 5, 2009·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Silvana C FariaClaude B Sirlin
Aug 9, 2011·European Radiology·Doenja M J LambregtsRegina G H Beets-Tan
May 29, 2012·Journal of Hepatology·Miloslav PolasekPeter Caravan
Nov 22, 2013·Journal of Magnetic Resonance Imaging : JMRI·Stephan W AndersonHernan Jara
Jan 1, 2014·Journal of Computer Assisted Tomography·Jeong Hee YoonByung-Ihn Choi
Apr 16, 2015·European Journal of Gastroenterology & Hepatology·Doenja M J LambregtsRegina G H Beets-Tan
Apr 29, 2015·Journal of Hepatology·Christian TrautweinMassimo Pinzani
Nov 20, 2016·Journal of Magnetic Resonance Imaging : JMRI·Xin-Xing HuSheng-Xiang Rao
Nov 2, 2017·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Shuangshuang XieWen Shen

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