Histogram Analysis of Diffusion Weighted Imaging in Low-Grade Gliomas: in vivo Characterization of Tumor Architecture and Corresponding Neuropathology

Frontiers in Oncology
Georg Alexander GihrStefan Schob

Abstract

Background: Low-grade gliomas (LGG) in adults are usually slow growing and frequently asymptomatic brain tumors, originating from glial cells of the central nervous system (CNS). Although regarded formally as "benign" neoplasms, they harbor the potential of malignant transformation associated with high morbidity and mortality. Their complex and unpredictable tumor biology requires a reliable and conclusive presurgical magnetic resonance imaging (MRI). A promising and emerging MRI approach in this context is histogram based apparent diffusion coefficient (ADC) profiling, which recently proofed to be capable of providing prognostic relevant information in different tumor entities. Therefore, our study investigated whether histogram profiling of ADC distinguishes grade I from grade II glioma, reflects the proliferation index Ki-67, as well as the IDH (isocitrate dehydrogenase) mutation and MGMT (methylguanine-DNA methyl-transferase) promotor methylation status. Material and Methods: Pre-treatment ADC volumes of 26 LGG patients were used for histogram-profiling. WHO-grade, Ki-67 expression, IDH mutation, and MGMT promotor methylation status were evaluated. Comparative and correlative statistics investigating the association between...Continue Reading

References

Jul 9, 1999·The Anatomical Record·S Mori, P B Barker
Oct 4, 2006·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Elizabeth M Charles-Edwards, Nandita M deSouza
Aug 20, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R SoffiettiW Wick
Mar 11, 2011·Cancer·Adrian IshkanianArjun Sahgal
Oct 27, 2012·JAMA : the Journal of the American Medical Association·Asgeir S JakolaOle Solheim
Nov 9, 2012·Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae·Yue YinRui Zhao
Mar 28, 2013·Current Neurology and Neuroscience Reports·Adam L CohenHoward Colman
Mar 26, 2014·The Oncologist·Deborah A ForstTracy T Batchelor
Oct 1, 2014·British Journal of Cancer·N Just
Jan 23, 2015·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Patricia SvolosIoannis Tsougos
Mar 21, 2017·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Stefan SchobAlexey Surov
Sep 3, 2017·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Hans-Jonas MeyerAlexey Surov

❮ Previous
Next ❯

Citations

Nov 28, 2020·AJNR. American Journal of Neuroradiology·A P BhandariA Lasocki
Aug 11, 2021·Neurologia Medico-chirurgica·Manabu KinoshitaHaruhiko Kishima

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques
biopsy
PCR
light microscopy

Software Mentioned

DICOM
GraphPad Prism
LAS
Matlab
GraphPad

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.