Histogram analysis of DTI-derived indices reveals pontocerebellar degeneration and its progression in SCA2

PloS One
Mario MascalchiStefano Diciotti

Abstract

To assess the potential of histogram metrics of diffusion-tensor imaging (DTI)-derived indices in revealing neurodegeneration and its progression in spinocerebellar ataxia type 2 (SCA2). Nine SCA2 patients and 16 age-matched healthy controls, were examined twice (SCA2 patients 3.6±0.7 years and controls 3.3±1.0 years apart) on the same 1.5T scanner by acquiring T1-weighted and diffusion-weighted (b-value = 1000 s/mm2) images. Cerebrum and brainstem-cerebellum regions were segmented using FreeSurfer suite. Histogram analysis of DTI-derived indices, including mean diffusivity (MD), fractional anisotropy (FA), axial (AD) / radial (RD) diffusivity and mode of anisotropy (MO), was performed. At baseline, significant differences between SCA2 patients and controls were confined to brainstem-cerebellum. Median values of MD/AD/RD and FA/MO were significantly (p<0.001) higher and lower, respectively, in SCA2 patients (1.11/1.30/1.03×10(-3) mm2/s and 0.14/0.19) than in controls (0.80/1.00/0.70×10(-3) mm2/s and 0.20/0.41). Also, peak location values of MD/AD/RD and FA were significantly (p<0.001) higher and lower, respectively, in SCA2 patients (0.91/1.11/0.81×10(-3) mm2/s and 0.12) than in controls (0.71/0.91/0.63×10(-3) mm2/s and 0.18). ...Continue Reading

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Citations

Dec 27, 2019·Biostatistics·Jordan D DworkinRussell T Shinohara
Aug 23, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Polina A Egorova, Ilya B Bezprozvanny
Feb 9, 2020·International Journal of Molecular Sciences·Mario Mascalchi, Alessandra Vella
Apr 13, 2019·Nature Reviews. Disease Primers·Thomas KlockgetherHenry L Paulson
Dec 15, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Stefano OrsoliniStefano Diciotti
Jun 25, 2021·Physics in Medicine and Biology·Jorge Perez-GonzalezVerónica Medina-Bañuelos

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Software Mentioned

FSL FLIRT ( FMRIB Linear Image Registration Tool
TBSS
Bash shell scripts
CAMINO
house
DTI
FSL
FDT FMRIB Diffusion Toolbox
TK
FSL brain extraction tool ( BET )

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