PMID: 8614240Mar 3, 1995Paper

Histogranin, a modified histone H4 fragment endowed with N-methyl-D-aspartate antagonist and immunostimulatory activities

Life Sciences
Simon LemaireIrma B Lemaire

Abstract

Histogranin is a naturally-occurring pentadecapeptide with a structure 80% homologous with that a fragment-(86-100) of histone H4. First isolated from bovine adrenal medulla, the peptide was also shown to be present in the pituitary, brain, adrenal glands, blood plasma, lungs and spleen. At the subcellular level, histogranin is concentrated in secretory vesicles and it is released from perfused bovine adrenal glands 15-35 min after stimulation with carbamylcholine as opposed to catecholamines and [Leu5]enkephalin which are released immediately after stimulation. Rat brain membranes possess specific binding sites for [125I][Ser1]histogranin with characteristics of a receptor, namely high affinity, saturability, reversibility and sensitivity to heat and proteolytic enzyme treatments. Intracerebroventricular injections of synthetic histogranin (10-100 nmol) in mice protect them against N-methyl-D-aspartate (NMDA)-induced convulsions without affecting convulsions induced by (R,S)-alpha-amino-3-hydroxy -5-methyl-4-isoxazole-propionate (AMPA), kainate and bicuculline. The peptide also binds to specific sites on human peripheral blood mononuclear cells and it evokes the release of tumor necrosis factor-alpha (TNF), interleukin-1 (IL-1...Continue Reading

References

Sep 1, 1978·The American Journal of Psychiatry·R M Allen, S J Young
Jan 1, 1991·Life Sciences·K WilliamsP B Molinoff
Jan 1, 1991·Annual Review of Pharmacology and Toxicology·E H Wong, J A Kemp
May 1, 1990·Immunology Today·D N KhansariR E Faith
Jan 1, 1990·Annual Review of Immunology·J Van Snick
Dec 1, 1985·Archivum Histologicum Japonicum = Nihon Soshikigaku Kiroku·H Kondo
Dec 19, 1989·European Journal of Pharmacology·F J RomanJ L Junien
Jun 15, 1989·Cancer·M J Wizenberg
Jan 1, 1986·Nucleic Acids Research·D E Wells
Apr 1, 1984·Canadian Journal of Physiology and Pharmacology·S LemaireR Calvert
Mar 24, 1994·Nature·M FarrantS G Cull-Candy
Aug 24, 1993·European Journal of Pharmacology·R BergeronC De Montigny
Aug 16, 1993·Biochemical and Biophysical Research Communications·S LemaireA V Ravindran

❮ Previous
Next ❯

Citations

Sep 5, 1995·European Journal of Pharmacology·T MauriceS Lemaire
Mar 5, 2016·Future Microbiology·Marloes HoeksemaKevan L Hartshorn
Aug 15, 2006·Neuroscience Letters·Y H ChiangY Wang
Aug 17, 2005·Virology·Jianfeng XuErnest F Terwilliger
Apr 20, 2007·Neuroscience Letters·Ian D HentallJacqueline Sagen
Jan 29, 2016·Cell Transplantation·Stanislava JergovaJacqueline Sagen
Jun 3, 2005·Cell Transplantation·Farinaz NasiriNezhad, Jacqueline Sagen
Dec 26, 2017·Frontiers in Molecular Neuroscience·Stanislava JergovaJacqueline Sagen
Jan 14, 2004·The Journal of Pharmacology and Experimental Therapeutics·Hoang-Thanh LeSimon Lemaire
Jul 27, 2000·Annals of the New York Academy of Sciences·M H OssipovF Porreca

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.