PMID: 6112Apr 23, 1976

Histologic and enzymatic studies of the mesolimbic and mesostriatal serotonergic pathways

Brain Research
M A GeyerA J Mandell


Selective lesions of the dorsal (B7), median (B8), or lateral (B9) raphe nuclei were made stereotaxically in male rats 4 weeks before sacrifice. The extent of damage to each raphe nucleus was quantified histologically by means of a simplified formaldehyde histochemical method for visualization of serotonin in cryostat sections. A detailed mapping of the distribution of the yellow-fluorescent raphe perikarya provided the basis for quantification. Tryptophan hydroxylase activity was measured in 6 forebrain regions from each animal, and the results were correlated with the per cent damage to each raphe nucleus. Tyrosine hydroxylase was also assayed in 5 of these regions; it was not significantly affected by any of the raphe lesions. Dorsal raphe lesions reduced tryptophan hydroxylase activity in the striatum, thalamus, cortex, and hypothalamus, but not in the septal nuclei or hippocampus. Damage to B8 resulted in decrements in this serotonergic enzyme in the septal nuclei, hippocampus, cortex, and hypothalamus, but not in the striatum or thalamus. Lesions of the scattered B9 cells had no significant effect on enzyme activity in any region examined. These data suggest that the dorsal and median raphe nuclei provide two distinct tho...Continue Reading


Sep 24, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·D MathenK P Bhatia
Feb 24, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·G Becker, D Berg
May 1, 1996·Movement Disorders : Official Journal of the Movement Disorder Society·K J Bharucha, K D Sethi
May 31, 1978·Psychopharmacology·S D Glick, R D Cox
Apr 29, 1977·Psychopharmacology·S D Glick, R D Cox
Aug 7, 1978·Acta Neuropathologica·K JellingerP Kothbauer
Aug 1, 1985·Biulleten' eksperimental'noĭ biologii i meditsiny·T A ZamoshchinaA S Saratikov
May 15, 1978·European Journal of Pharmacology·P C Waldmeier, B Fehr
Sep 15, 1978·European Journal of Pharmacology·J Davies, P Tongroach
Mar 1, 1979·European Journal of Pharmacology·P C WaldmeierK Stöcklin
May 15, 1979·European Journal of Pharmacology·P C Waldmeier, A A Delini-Stula
Jun 10, 1981·European Journal of Pharmacology·J N JoyceC Van Hartesveldt
Oct 28, 1983·European Journal of Pharmacology·E H Lee, M A Geyer
Oct 20, 1980·Life Sciences·S C Gerson, R J Baldessarini
Oct 1, 1978·Physiology & Behavior·F G Graeff, N G Silveira Filho
Oct 1, 1979·Physiology & Behavior·K E AsinE W Kent
Jan 1, 1979·Physiology & Behavior·M Le Moal, M E Olds
May 1, 1982·Physiology & Behavior·D Wirtshafter, K E Asin
Feb 1, 1979·Pharmacology, Biochemistry, and Behavior·M A GeyerL R Petersen
Jan 1, 1980·Pharmacology, Biochemistry, and Behavior·F G Graeff, J N Rawlins


Aug 15, 1972·Life Sciences. Pt. 1: Physiology and Pharmacology·S Knapp, A J Mandell
Jan 1, 1974·Life Sciences·A J MandellL L Hsu
Sep 1, 1958·Brain : a Journal of Neurology·W J NAUTA
Sep 1, 1964·Analytical Biochemistry·T NAGATSUS UDENFRIEND

Related Concepts

Limbic System
Adrenal Cortex Diseases
Accessory Atrioventricular Bundle
Organum Vasculosum Laminae Terminalis
Lentiform Nucleus Structure
Tryptophan 5-monooxygenase
Neural Pathways
Reticular Formation
Functional Cerebral Localization
Insula of Reil

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.