PMID: 8609255Mar 1, 1996Paper

Histologic and immunohistochemical features in biopsy sites in which bovine collagen matrix was used for hemostasis

Journal of the American Academy of Dermatology
K J SmithJ Beard

Abstract

Bovine collagen matrix (Helistat and Helatene), which is used primarily for hemostasis, decreases wound contracture in skin biopsy sites and promotes wound granulation. Our purpose was to evaluate excision specimens of previous biopsy sites to determine whether there are histologic differences between cases in which bovine collagen matrix was used for hemostasis and those in which it was not used. Thirty-two diagnostic punch biopsies were done with hemostasis obtained with bovine collagen matrix in 24 biopsies and by pressure alone in eight. The biopsy sites were reexcised at various time intervals, and the histologic and immunohistochemical features were evaluated and compared. In specimens in which collagen matrix was used, migration of stromal and epithelial cells along the bovine collagen matrix was evident by 2 days and had progressed rapidly by 4 days. Around and within the matrix hyaluronic acid increased during the first 8 to 10 days. Initially stromal cells stained with CD34 and reticulum fibers were present at 8 to 10 days. AT 12 to 15 days, factor XIIIa+ stromal cells were present within the matrix, and host collagen fibers were present and well-oriented within the degenerating matrix. Biopsy specimens allowed to hea...Continue Reading

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Citations

Oct 20, 2005·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Yasuko Tomizawa
Jul 27, 1999·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·S A KolenikD J Leffell
Dec 29, 2000·The Laryngoscope·B A WambachG D Josephson
Feb 17, 1998·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·T S Alster
Apr 8, 2010·Critical Care : the Official Journal of the Critical Care Forum·Rolf RossaintUNKNOWN Task Force for Advanced Bleeding Care in Trauma
Dec 29, 2000·American Journal of Veterinary Research·S F SwaimS L Coolman
Jun 22, 2006·The Veterinary Clinics of North America. Small Animal Practice·Bonnie Grambow Campbell
Sep 3, 2008·The British Journal of Surgery·H SeyednejadA M Seifalian
Apr 14, 2016·Critical Care : the Official Journal of the Critical Care Forum·Rolf RossaintDonat R Spahn
Apr 15, 2008·Burns : Journal of the International Society for Burn Injuries·Fatih UygurBahattin Celikoz
Apr 6, 2018·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Victoria AsfourRizwan Attia
Mar 29, 2019·Critical Care : the Official Journal of the Critical Care Forum·Donat R SpahnRolf Rossaint

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