PMID: 428994Jan 1, 1979Paper

Histologic and morphometric study of chronic gastritis in alcoholic patients

Human Pathology
F F ParlC S Pitchumoni

Abstract

The effect of chronic alcohol ingestion on the gastric mucosa was determined in 96 patients in whom gastroscopy was performed because of upper gastrointestinal symptoms. Seventy-two patients were classified as alcoholics and 24 patients as nonalcoholics. In all cases biopsy specimens were taken from the fundus and antrum. The diagnoses of chronic superficial and atrophic gastritis were based on conventional histologic criteria and a morphometric technique utilizing quantitation of the chronic inflammatory cells in the lamina propria. Alcoholic patients were found to have a higher incidence of chronic gastritis of the antrum than nonalcoholics (p less than 0.001). Fundic involvement was also more common, probably accounting for the decreased gastric acid output described in chronic alcoholic patients. Finally, gastritis was more severe in the alcoholics; below 45 years of age chronic atrophic gastritis was seen only in alcoholics. We conclude that chronic gastritis develops more frequently in alcoholic patients and evolves into chronic atrophic gastritis at an earlier age than in nonalcoholic subjects.

References

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Citations

Aug 1, 1986·Alcoholism, Clinical and Experimental Research·A KeshavarzianJ Wobbleton
Apr 1, 1990·Journal of Clinical Pathology·G M SobalaM F Dixon
Dec 1, 1989·Alcoholism, Clinical and Experimental Research·M RabinovitzJ S Gavaler
Mar 27, 2009·Alcoholism, Clinical and Experimental Research·Akira YokoyamaKatsuya Maruyama
Apr 1, 2000·Addiction Biology·T Chiba, S F Phillips
Jun 1, 1997·The Journal of Laboratory and Clinical Medicine·K S SalmelaR P Roine
Aug 1, 1993·Journal of Hepatology·A G FraserA K Burroughs
May 1, 1982·Human Pathology·H Goldman, D A Antonioli

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Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.