Histologic and ultrastructural changes in corneas with granular and macular dystrophy after excimer laser phototherapeutic keratectomy

Cornea
Nóra SzentmáryGottfried O H Naumann

Abstract

The histologic changes after phototherapeutic keratectomy (PTK) in corneas with granular and macular dystrophy were studied. We studied 3 corneas of 2 patients (1 granular, 2 macular dystrophy), who underwent penetrating keratoplasty (PK) at 0.8, 2.16, and 3.25 years after PTK; and 11 corneas (controls) from 10 PK patients (5 granular, 6 macular dystrophy) by light microscopy and by transmission electron microscopy. PTK was performed by using the Asclepion-Meditec MEL 60 excimer laser. After PTK the epithelium (15-40 versus 5-100 microm), and the upper stromal collagen lamella thickness (50-75 versus 50-100 microm) were less irregular than for the controls. In 1 eye (macular dystrophy) 10 months after PTK an acid mucopolysaccharide-positive band was detected in the subepithelial stroma, which could be removed by hyaluronic acid digestion. This fact suggests that it was "haze" formed after PTK, rather than a subepithelial recurrence of the dystrophy. All PTK corneas had deposits in the mid- and posterior stroma. Concerning controls, deposits were detected under the epithelium in all corneas. Electron microscopy of the study corneas revealed a mostly continuous basal lamina, occasionally forming projections into the subepithelial...Continue Reading

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Citations

Sep 1, 2006·Photomedicine and Laser Surgery
Apr 8, 2009·Cornea·Jayne S WeissGordon K Klintworth
Jan 15, 2008·Survey of Ophthalmology·Sujata Das, Berthold Seitz
Jan 1, 2011·Ophthalmology and Eye Diseases·Khalid Al ArfajRoberto Pineda
Apr 22, 2009·Current Opinion in Ophthalmology·Kalliopi Stasi, Roy S Chuck
Nov 1, 2012·Asia-Pacific Journal of Ophthalmology·Kunyong XuVishal Jhanji
Feb 1, 2019·Veterinary Ophthalmology·Claudia BusseIsabelle Raymond
Jul 16, 2019·Survey of Ophthalmology·Ritu NagpalNamrata Sharma
Jun 15, 2007·Current Opinion in Ophthalmology
Dec 6, 2006·The Ocular Surface·Brandon D Ayres, Christopher J Rapuano

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