PMID: 16639286Apr 28, 2006Paper

Histologic changes in the eustachian tube mucosa of rats after short-term exposure to cigarette smoke

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Il-Woo LeeKyong-Myong Chon

Abstract

It is generally accepted that cigarette smoke is a major risk factor for middle ear disease. However, the literature is void of articles addressing the direct relationship between cigarette smoke exposure and middle ear disease. Furthermore, there are many conflicting opinions concerning the role of cigarette smoke in the pathogenesis of middle ear disease. The purpose of this study was to evaluate the effects of cigarette smoke on the Eustachian tube mucosa. Thirty healthy 150 to 230 g Sprague Dawley rats with normal middle ears were used. The animals were divided into six groups of five. Five experimental groups (N=5 each) were exposed to a domestic cigarette (This, tar 7.0 mg, nicotine 0.75 mg) every 30 minutes (total 2.5 hours, 5 cigarettes total) on a daily basis in a smoking chamber for 1, 2, 4, 6, or 8 weeks. A control group (N=5) was placed in the same chamber without exposure to cigarette smoke. After exposure, the animals were sacrificed and cross sections of the Eustachian tubes were prepared. Histologic changes of the Eustachian tube mucosa were observed through light and electron microscopes. Loss of cilia, goblet cell depletion, and squamous metaplasia of the Eustachian tube mucosa were observed following exposure...Continue Reading

References

Mar 1, 1977·The Annals of Otology, Rhinology, and Laryngology·M Tos, K Bak-Pedersen
Mar 1, 1976·The Annals of Otology, Rhinology, and Laryngology·M Tos, K Bak-Pedersen
Sep 1, 1992·The Annals of Otology, Rhinology, and Laryngology·S MatsuneH Takahashi
Nov 1, 1988·The Journal of Laryngology and Otology·A E Hinton, G Buckley
Jan 1, 1984·Acta Oto-laryngologica. Supplementum·P B Van Cauwenberge
Jan 1, 1995·Acta Oto-laryngologica·A M AgiusL A Smallman
Mar 1, 1995·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·B W Blakley, J E Blakley
Oct 1, 1994·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·P J AntonelliG S Giebink
May 1, 1994·Archives of Otolaryngology--head & Neck Surgery·Y FinkelsteinY Zohar
Nov 30, 1999·International Journal of Pediatric Otorhinolaryngology·D GryczyńskaA Zakrzewska
May 1, 2001·Human & Experimental Toxicology·E Nelson
Feb 1, 2002·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Marc G DubinJiri P Prazma
Sep 6, 2003·American Journal of Respiratory and Critical Care Medicine·Rong D WangAndrew Churg
Nov 19, 2003·Molecular and Cellular Biochemistry·Pallab MaityUday Bandyopadhyay

❮ Previous
Next ❯

Citations

Dec 8, 2011·The Journal of Sexual Medicine·Min Gu ParkDu Geon Moon
Nov 3, 2009·American Journal of Otolaryngology·Soo-Keun KongSoo-Geun Wang
Aug 19, 2015·Journal of Pharmacological and Toxicological Methods·Mandeep Singh KapoorSurendra H Bodakhe
May 7, 2009·The Laryngoscope·David M KaylieC Gary Jackson
Nov 8, 2012·The Annals of Otology, Rhinology, and Laryngology·Daniel H CoelhoAristides Sismanis
Dec 11, 2013·Annals of Plastic Surgery·Anajara GazzalleJefferson Luis Braga-Silva
Sep 5, 2015·Current Opinion in Otolaryngology & Head and Neck Surgery·Justin S Golub, Ravi N Samy
Jun 9, 2016·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Matthew D CoxJohn L Dornhoffer
Jun 9, 2016·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·James R DornhofferJohn L Dornhoffer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Archives of Otolaryngology--head & Neck Surgery
O C IlicaliI Savaş
Archives of Pediatrics & Adolescent Medicine
C E Adair-Bischoff, R S Sauve
Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Per Cayé-Thomasen, Mirko Tos
© 2022 Meta ULC. All rights reserved