PMID: 2107021Apr 1, 1990Paper

Histologic changes induced by intraperitoneal chemotherapy with 5-fluorouracil and mitomycin C in patients with peritoneal carcinomatosis from cystadenocarcinoma of the colon or appendix

Cancer
P H SugarbakerR Pascal

Abstract

Intraperitoneal chemotherapy with mitomycin C and 5-fluorouracil has been used to rescue patients from peritoneal carcinomatosis after perforated cystadenocarcinoma of the large bowel or appendix. A staging celiotomy was used to asses the results of therapy. In nine patients tumor was recovered from the abdominal cavity and was subjected to careful histopathologic examination. The posttreatment appearance of the tumor was compared with that before treatment. Also, tumor deposits harvested from these same patients, but from anatomic sites not directly exposed to chemotherapy were examined. The most striking findings observed in treated patients were as follows: (1) the marked reduction in the number of foci of atypical neoplastic epithelium lining the mucin globules, and (2) atrophy and degeneration of the atypical neoplastic epithelium. All treated patients showed these effects but they were not in all sampled tumor specimens, suggesting nonuniform drug distribution in the abdominal cavity and limited penetration of chemotherapy into tumor. The authors conclude that intraperitoneal chemotherapy produces marked histologic changes in mucinous tumors when there is direct contact between tumor and intracavitary drugs.

References

Apr 1, 1976·Cancer·D A Symonds, A L Vickery

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Citations

Jul 1, 1996·Seminars in Surgical Oncology·J R Cintron, R K Pearl
Jan 1, 1991·Journal of Surgical Oncology. Supplement·P H Sugarbaker
Aug 1, 1995·Diseases of the Colon and Rectum·R CortinaR R Perry
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May 1, 1993·Trends in Pharmacological Sciences·T A Waldmann
Apr 18, 2002·Transplantation Proceedings·M RiñónM D García Masdevall
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Jan 1, 1995·Annals of Surgery·P H Sugarbaker
Jan 1, 1995·Journal of Gastroenterology and Hepatology·S Y HsiehC S Wu
Jun 17, 2005·Nephrology·Hideki Kawanishi
Jun 21, 1991·Science·T A Waldmann
Nov 5, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·F RovielloD Marrelli
Jul 2, 2008·Current Problems in Surgery·Robert M SmeenkVictor J Verwaal
May 2, 2003·Journal of Surgical Oncology·Faheez MohamedPaul H Sugarbaker
Apr 20, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·P H Sugarbaker
Nov 18, 2005·Journal of Pediatric Surgery·Matthew J BlechaMary Beth Madonna
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Jun 1, 1996·World Journal of Surgery·P H SugarbakerM von Meyerfeldt
Mar 17, 2005·The International Journal of Artificial Organs·H Kawanishi

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