Histologic comparison of cultured epithelial autograft and meshed expanded split-thickness skin graft

The Journal of Burn Care & Rehabilitation
M PutlandV A Tron

Abstract

Histologic appearance of cultured epithelial autograft (CEA) biopsies obtained up to 2100 days after application from patients with burn injuries differs from time-matched, meshed expanded autograft. The CEA interface with underlying bed remained flat for up to 3 years in three of four patients. CEA epidermal rete ridges, if formed subsequently, were fewer, thinner, and shorter, whereas expanded split-thickness skin grafts had well-defined rete ridges after 1 year. CEA basal layer remained separated from its bed up to 50 days after application, and late blister formation was seen on occasion for up to 3 years. The underlying bed was homogeneous up to 2 years; later some beds demonstrated differentiation with superficial, fine, filamentous collagen fibers and deeper, thick collagen fibers. Fine elastin filaments were initially identified in the superficial bed after 1 year in some specimens and in all after 3 years. Delay in rete ridge formation may explain poor adherence and poor stability.

Citations

Aug 19, 2011·Cell and Tissue Banking·Jana DragúňováValéria Jarabinská
Nov 19, 2003·Clinics in Plastic Surgery·H BannaschG B Stark
Feb 6, 2002·Clinics in Plastic Surgery·Ryan A Stanton, David A Billmire
Nov 3, 2001·Matrix Biology : Journal of the International Society for Matrix Biology·F BerthodF A Auger
Jan 10, 2001·Plastic and Reconstructive Surgery·G G Hallock
Jul 27, 2004·The Journal of Burn Care & Rehabilitation·D L ChesterR P G Papini
Apr 28, 2004·Plastic and Reconstructive Surgery·Moshe Shlomo Fayman, Estelle Potgieter
Oct 27, 2010·The Journal of Dermatological Treatment·Xinlei HuChunmao Han
Mar 24, 2009·Burns : Journal of the International Society for Burn Injuries·S Elizabeth JamesPhilip M Gilbert
Apr 3, 2007·Burns : Journal of the International Society for Burn Injuries·Bishara S Atiyeh, Michel Costagliola
Jan 10, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·H BannaschM Föhn
Jun 1, 1997·The British Journal of Dermatology·F Berthod, O Damour
Jun 4, 2020·Tissue Engineering. Part a·Megan M MalaraHeather M Powell
Jun 2, 2018·Burns and Trauma·Zhe Li, Peter Maitz

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