PMID: 9194582May 1, 1997Paper

Histologic criteria for the diagnosis of erythrodermic mycosis fungoides and Sézary syndrome: a critical reappraisal

Journal of Cutaneous Pathology
S KohlerB R Smoller

Abstract

It is often difficult to make a clinical or histologic diagnosis of erythrodermic mycosis fungoides (MF) and Sezary syndrome (SS). Whereas the histologic parameters for making a diagnosis of MF with well-developed patch and plaque stage lesions are clearly defined, the same criteria appear to be less relevant for diagnosing MF in patients with erythroderma secondary to the disease. In order to better define the histologic features of erythrodermic MF and SS, we studied 28 routine histologic sections of 17 patients with known erythrodermic MF or SS. Sections were reviewed independently by 2 dermatopathologists. Each of 24 parameters was scored semi-quantitatively and the data were compared to data previously reported from a group of 64 patients with limited patch and plaque stage lesions of MF. When compared to biopsies from patients with limited patch/plaque lesions, biopsies taken from erythrodermic patients displayed more parakeratosis (p=0.0492) and acanthosis (p=0.0046), less disproportionate epidermotropism, fewer lymphocytes aligned within the basal layer (p=0.0045), fewer hyperconvoluted cells in the epidermis, more dermal hyperconvoluted cells (p=0.0191), more papillary dermal fibrosis (p=0.0002), more prominent teleang...Continue Reading

References

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Citations

Jan 9, 2004·Hematology/oncology Clinics of North America·Bruce R SmollerSean J Whittaker
Jun 19, 2010·The American Journal of Dermatopathology·Caroline Ram-WolffNicolas Ortonne
Aug 7, 1998·Journal of Cutaneous Pathology·B R SmollerY H Kim
Mar 4, 2005·American Journal of Clinical Pathology·A Hafeez DiwanDan Jone
Sep 7, 2000·Ceskoslovenská patologie·F FakanS Námĕstek
May 17, 2012·Annals of Saudi Medicine·Zeljko PrkaRajko Kusec
Nov 6, 2008·Journal of Cutaneous Pathology·Bruce R Smoller
Aug 18, 2005·The Journal of Biological Chemistry·Hakju KwonWarner C Greene
Jan 18, 2006·Journal of Cutaneous Pathology·Eric C Vonderheid
Dec 20, 2007·American Journal of Clinical Pathology·Katalin KelemenLoann C Peterson
Apr 3, 2012·Journal of Clinical Apheresis·Kimberly W Sanford, Rasheed A Balogun
Jun 16, 2004·Journal of the European Academy of Dermatology and Venereology : JEADV·D V KazakovW Kempf
Oct 10, 2015·Advances in Anatomic Pathology·Meera Mahalingam, Vijaya B Reddy
Jul 16, 2003·Journal of Cutaneous Pathology·Erika M BalfourBruce R Smoller

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