PMID: 9557779Apr 29, 1998Paper

Histologic differentiation of desmoplastic melanoma from cicatrices

The American Journal of Dermatopathology
N K Kaneishi, C J Cockerell

Abstract

Desmoplastic malignant melanoma (DMM) is a rare variant of melanoma that can be very difficult to diagnose correctly both clinically and histologically. The problem is compounded by the fact that many lesions persist at previous biopsy or excision sites so that scar tissue is often present admixed with or adjacent to the spindle cell neoplasm which may exhibit fibroblastic differentiation itself. In order to assess this problem, we compared and contrasted the histologic features of six DMM with 15 examples of cicatrices from various sources. Mature scars were readily differentiated from DMM by light microscopy. In contrast, immature scar and DMM had many features in common including hypercellularity, nodular lymphoid infiltrates, myxoid stroma, and atypical nuclei. The presence of a melanocytic proliferation within the epidermis above the dermal component, neurotropism, and S-100 and/or HMB-45 positivity of neoplastic cells were the only features that permitted reliable differentiation between the two. Clinical correlation and review of previous biopsy specimens are crucial in preventing a delayed diagnosis of DMM. Re-excision is advised in all questionable cases.

References

Aug 1, 1979·The American Journal of Surgical Pathology·R J Reed, D D Leonard
Mar 1, 1992·World Journal of Surgery·B M SmithersJ H Little
Jan 1, 1992·The British Journal of Dermatology·M E Fallowfield, M G Cook
Feb 20, 1992·International Journal of Cancer. Journal International Du Cancer·C Fearns, E B Dowdle
Mar 11, 1992·Histopathology·J A BruijnR L Barnhill
May 1, 1992·Journal of the American Academy of Dermatology·D C WhitakerA C Smith
May 1, 1989·The American Journal of Surgical Pathology·S Jain, P W Allen
Oct 1, 1982·The American Journal of Dermatopathology·E BryantJ R Manaligod
Jun 1, 1981·Journal of Cutaneous Pathology·T F WarnerJ H Brandenberg
Feb 1, 1994·The American Journal of Dermatopathology·A AnsteyE W Jones
May 1, 1995·Journal of the American Academy of Dermatology·H G SkeltonG P Lupton
May 1, 1995·Journal of the American Academy of Dermatology·R W Sagebiel
Mar 1, 1995·Plastic and Reconstructive Surgery·N WeinzweigR J Yetman
Oct 1, 1993·The British Journal of Dermatology·A AnsteyE W Jones
Jan 1, 1994·The Annals of Otology, Rhinology, and Laryngology·J G Batsakis, A K Raymond
Sep 1, 1995·Cutis·W B ShelleyN Y Talanin

❮ Previous
Next ❯

Citations

Jul 14, 1999·The American Journal of Surgical Pathology·G R HarrisV G Prieto
Oct 19, 2004·The American Journal of Surgical Pathology·Klaus J BusamMary S Brady
May 23, 2008·The American Journal of Dermatopathology·Luis Soares de AlmeidaManuel Marques Gomes
May 26, 2011·The American Journal of Dermatopathology·Bob N BernabaDavid S Cassarino
Mar 16, 2006·Annals of Surgical Oncology·Katherine E PostherHilliard F Seigler
Feb 14, 2002·Journal of Cutaneous Pathology·Nandan V KamathNancy S House
May 10, 2011·Clinics in Laboratory Medicine·Klaus J Busam
Oct 19, 2010·Journal of the American Academy of Dermatology·Rossitza LazovaAlicia C Sigal
Sep 1, 2009·Surgical Pathology Clinics·Klaus J Busam
Mar 14, 2007·Mayo Clinic Proceedings·Svetomir N MarkovicUNKNOWN Melanoma Study Group of the Mayo Clinic Cancer Center
Aug 20, 2010·Histopathology·Ossama Abbas, Meera Mahalingam
Jul 27, 2010·Journal of Cutaneous Pathology·Frances Ivette Ramos-HerberthSoheil S Dadras
May 20, 1999·Human Pathology·J M WhartonM C Mihm
May 26, 2016·Seminars in Diagnostic Pathology·Mark R Wick
May 28, 2016·Seminars in Diagnostic Pathology·Mark R Wick
Apr 10, 2007·Mayo Clinic Proceedings·Svetomir N MarkovicUNKNOWN Melanoma Study Group of Mayo Clinic Cancer Center
Dec 27, 2012·Journal of the American Academy of Dermatology·Lucy L ChenAshfaq A Marghoob
Feb 26, 2005·Advances in Anatomic Pathology·Klaus J Busam
Jan 24, 2019·Applied Immunohistochemistry & Molecular Morphology : AIMM·Christopher A Febres-Aldana, John Alexis
Jul 27, 2002·The American Journal of Dermatopathology·Joe A Chorny, Ronald J Barr
Jan 8, 2019·F1000Research·Stephen M SchwartzMark W Majesky
May 23, 2007·Archives of Pathology & Laboratory Medicine·David J DiCaudoMark R Wick

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved