Histologic effects of the high-energy pulsed CO2 laser on photoaged facial skin

Plastic and Reconstructive Surgery
J M StuzinA M Kligman

Abstract

To delineate the histologic effects of laser resurfacing at photoaged skin, a protocol was designed to biopsy laser test sites in conjunction with adjacent actinically damaged skin at the time of rhytidectomy. Five patients with photodamaged skin underwent resurfacing of the preauricular region to examine the effect of increasing pulse energy and increasing number of passes on depth of dermal penetration. Histologic examination of these specimens showed that the depth of laser injury was dose-dependent. Increasing pulse energy created a deeper wound, and increasing the number of passes similarly produced a larger band of necrosis. Ten patients with photodamaged skin underwent resurfacing of the preauricular region 15 days to 6 months prior to undergoing a rhytidectomy. A comparison of the laser-resurfaced test spot with the adjacent untreated photodamaged skin demonstrated consistent histologic changes to both epidermis and dermis in all specimens examined. Following laser resurfacing, epidermal atrophy and atypia were eliminated, and all specimens exhibited a regeneration of epithelium that was normal in its morphology. Melanocytic hypertrophy and hyperplasia were corrected following treatment, although density and function of...Continue Reading

References

Apr 1, 1991·The Journal of Dermatologic Surgery and Oncology·R E FitzpatrickM P Goldman
Oct 1, 1990·The Journal of Dermatologic Surgery and Oncology·M Yaar, B A Gilchrest
Sep 1, 1989·Journal of the American Academy of Dermatology·B A Gilchrest
Sep 1, 1989·The Journal of Dermatologic Surgery and Oncology·H J Brody
Dec 1, 1986·The Journal of Dermatologic Surgery and Oncology·H J Brody, C W Hailey
May 1, 1985·Plastic and Reconstructive Surgery·A M KligmanH L Gordon
May 1, 1974·Plastic and Reconstructive Surgery·T J BakerD L Seckinger
Dec 29, 1969·JAMA : the Journal of the American Medical Association·A M Kligman
Jun 1, 1980·The Journal of Dermatologic Surgery and Oncology·S J Stegman
Aug 1, 1995·Annals of Plastic Surgery·C C Yang, C Y Chai
Oct 1, 1996·Plastic and Reconstructive Surgery·T S Alster, S Garg
Jan 1, 1997·Advances in Dermatology·R E Fitzpatrick
Aug 1, 1994·Journal of Clinical Laser Medicine & Surgery·C Weinstein

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Citations

Mar 1, 2002·Lasers in Surgery and Medicine·Bradley K DraperLillian B Nanney
Feb 26, 2000·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·M P GoldmanR E Fitzpatrick
Jul 24, 2002·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Elizabeth L Tanzi, Tina S Alster
Dec 4, 2002·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Tina S Alster, Jason R Lupton
Aug 14, 1998·Plastic and Reconstructive Surgery·G J Rosenberg
Aug 14, 1998·Plastic and Reconstructive Surgery·S S CollawnL O Vasconez
Feb 9, 1999·Plastic and Reconstructive Surgery·J M StuzinT M Baker
Jan 10, 2001·Plastic and Reconstructive Surgery·D S KirnB F Fink
Jul 7, 2000·Plastic and Reconstructive Surgery·A D Widgerow, S A Braun
Feb 24, 2001·Plastic and Reconstructive Surgery·C WeinsteinM Scheflan
Jun 8, 2001·Plastic and Reconstructive Surgery·T S Alster
Nov 17, 2001·Plastic and Reconstructive Surgery·G G Hallock
Feb 6, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Elizabeth L Tanzi, Tina S Alster
Apr 12, 2003·American Journal of Clinical Dermatology·David J Goldberg
Mar 29, 2014·Ageing Research Reviews·Márcio LorenciniHoward I Maibach
Sep 1, 1999·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·R A Massey, Y D Eliezri
Sep 1, 1999·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·G M MenakerR L Moy
Mar 19, 2011·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Sonal ChoudharyKeyvan Nouri
Oct 12, 2016·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Andrew M Read-FullerRichard A Finn
Jul 21, 2004·Facial Plastic Surgery Clinics of North America·Edwin F Williams, Ravi Dahiya
Apr 14, 2010·International Journal of Cosmetic Science·M O BodendorfU Paasch
Dec 20, 2007·Oral and Maxillofacial Surgery Clinics of North America·Steven A Guttenberg, Robert W Emery
Oct 21, 2016·Journal of Cutaneous and Aesthetic Surgery·Patrick J Buchanan, Robert H Gilman
Mar 31, 2015·Journal of Cosmetic Dermatology·Sana Mohammed Anayb BalegAsma Hamid
Aug 25, 1999·Journal of the American Academy of Dermatology·D RatnerD J Fader
Nov 8, 2017·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·R Thiesmann
Mar 9, 2004·Lasers in Surgery and Medicine·Shilesh IyerRichard E Fitzpatrick
May 15, 2001·Journal of Cutaneous Laser Therapy·M A TrellesJ Rigau
Aug 29, 2014·Lasers in Surgery and Medicine·Vidyunmala RamaprasadWarren S Grundfest
Oct 13, 2006·Lasers in Surgery and Medicine·Karin Kunzi-RappMichael Drosner
Feb 19, 2005·Lasers in Surgery and Medicine·Misbah Huzaira KhanR Rox Anderson
Mar 5, 2008·Plastic and Reconstructive Surgery·Arturo PradoPatricio Fuentes
Aug 31, 2006·Yonsei Medical Journal·Ju Hee LeeKwang Hoon Lee
Feb 15, 2002·Archives of Facial Plastic Surgery·Paulino E Goco, Fred J Stucker
Nov 20, 2008·Archives of Facial Plastic Surgery·Edward C Wu, Brian J F Wong
Aug 9, 2001·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·M A TrellesJ L Levy

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