Histologic Evaluation of Acellular Dermal Matrix Allografts in Humans

Clinical Advances in Periodontics
Jessica L OwensA Archontia Palaiologou

Abstract

Acellular dermal matrix (ADM) is a cell-free dermal matrix comprised of a structurally integrated basement membrane complex and extracellular matrix in which collagen bundles and elastic fibers are the main components. There are several commercially available ADM allografts that have different processing methods. This case series reports the histologic presentation of two of the most widely used ADM allografts, referred to as ADM-A and ADM-B, in patients that had specific situations involving reentry. Two patients referred to the Louisiana State University Department of Periodontics, New Orleans, Louisiana, with 1- to 3-mm recession of at least two non-contiguous sites needing soft tissue augmentation, were treated with appropriate mucogingival procedures using ADM-A or ADM-B. After ≈6 to 8 months of healing, and due to clinical findings that necessitated further periodontal procedures, small tissue biopsies were obtained and examined microscopically. All samples of ADM (A and B) analyzed after staining with hematoxylin and eosin had a generally similar appearance under light microscopic examination, which suggests they are both well incorporated into native tissues after 6 to 8 months of healing. When stained with Verhoeff-Van...Continue Reading

Citations

Sep 19, 2019·Clinical Advances in Periodontics·Khashayar Kordbacheh ChangiPhilip Kang

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