Histologic evaluation of periodontal attachment apparatus following the insertion of a biodegradable copolymer barrier in humans

Journal of Periodontology
S VuddhakanokF A Alger

Abstract

The purpose of this study was to histologically evaluate the effectiveness of polylactide:polyglycolide 50:50 (DL-PLGA) as a barrier to prevent epithelial migration and to promote new connective tissue attachment. Mucoperiosteal flaps were performed on 17 human teeth. DL-PLGA membrane was placed over the roots and alveolar bone. DL-PLGA was not placed over control teeth. Ninety days following surgery, block sections were obtained and processed for histologic evaluation. All specimens revealed a mean length of epithelial attachment within physiologic limits and recession of the gingival margin. There was little or no reattachment of the connective tissue. It is concluded that this copolymer barrier did not prevent epithelial migration nor enhance connective tissue attachment to human roots with severe horizontal bone loss and active periodontal disease.

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Citations

Aug 16, 2001·Journal of Biomedical Materials Research·A A IgnatiusF Palm
Aug 1, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·Y J ParkS J Lee
Mar 1, 1997·Annals of Periodontology·E E Machtei
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Nov 1, 2014·Maxillofacial Plastic and Reconstructive Surgery·Sang-Woon Lee, Seong-Gon Kim
Feb 1, 1995·Journal of Biomedical Materials Research·K NishimuraT Makita
May 13, 1999·Periodontology 2000·M S Reddy, M K Jeffcoat
Jun 19, 2001·Journal of Biomedical Materials Research·E MilellaV Bruno
May 13, 1999·Periodontology 2000·D N TatakisU M Wikesjö

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