PMID: 15384027Sep 24, 2004Paper

Histologic evolution of bone disease 6 months after successful kidney transplantation

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Elisa A S CruzAluizio B Carvalho

Abstract

The histologic patterns of bone disease, as well as the evolution of renal osteodystrophy after kidney transplantation (Tx), are not well defined. Information in this regard is scarce and contradictory. Before and 6 months after Tx, analysis of biochemical, hormonal, and bone histomorphometric parameters were performed. Twenty patients (14 men and 6 women) entered the study. Median age was 36.5 (range, 20 to 55) years, and median time on dialysis was 22 (9 to 88) months. Bone histomorphometric diagnoses at pre-Tx were adynamic bone disease, 12; mixed bone disease, 3; mild disease, 3; and osteitis fibrosa, 2. After Tx, 11 had adynamic bone disease; 8, mild disease; and 1, osteomalacia. As a whole, dynamic parameters improved significantly in patients who had adynamic bone. Five of the 12 with this diagnosis completely recovered their bone turnover. Pre-Tx hyperparathyroidism bone features improved or resolved, but 5 of the 8 patients had low-turnover bone disease (adynamic disease, 4; osteomalacia, 1). Three of them had persistence of aluminum and/or iron deposits on bone surface, and the other 2 had hypophosphatemia and high intact parathyroid hormone levels. Overall, biochemical parameters tended toward normalization. Serum in...Continue Reading

Citations

Feb 26, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Antoine BouquegneauArif Khwaja
Oct 30, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Hala M AlshayebStuart M Sprague
Nov 7, 2007·Endocrinology and Metabolism Clinics of North America·Neveen A T Hamdy
Mar 29, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Patricia L Adams
Jun 6, 2013·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Masafumi FukagawaUNKNOWN Japanese Society for Dialysis Therapy
Oct 16, 2010·Pediatric Transplantation·Wacharee Seeherunvong, Myles Wolf
Nov 12, 2014·International Urology and Nephrology·Evangelia DounousiVassilios Liakopoulos
Jan 28, 2014·Transplantation Reviews·Miklos Z MolnarSuphamai Bunnapradist
Jun 22, 2016·Clinical Transplantation·Stephanie M Toth-ManikowskiCraig E Gordon
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Jul 10, 2018·Clinical Transplantation·Ashish K SharmaRosemary Masterson
Oct 12, 2018·Internal Medicine Journal·Jasna AleksovaRichard J MacIsaac
Apr 25, 2007·Transplantation·Mario Abbud-FilhoFrancis L Delmonico
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Klaus Olgaard, Ewa Lewin
Mar 12, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Katherine Wesseling-Perry, Justine Bacchetta
Jan 5, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H McKeeJ D Adachi
May 16, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Satu KeronenEero Honkanen

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