PMID: 9170388May 1, 1997Paper

Histologic examination of meniscal repair in rabbits

Clinical Orthopaedics and Related Research
N TakeuchiH Iwata

Abstract

After a cylindrical defect was made in the anterior segment of the lateral meniscus in rabbits, the meniscus was examined postoperatively at 2, 8, and 13 weeks. Horizontal sections were prepared at a central level of the meniscus from each sample and stained with hematoxylin and eosin, Safranin O, and Masson trichrome. In addition, part of the tissue was immunologically stained with antibodies to chondroitin-4-sulfate, chondroitin-6-sulfate, keratan sulfate, and Type II collagen. Hematoxylin and eosin stained specimens were analyzed for repair tissue by microscopic study, and the cells observed in repair tissue were found to change from fibroblastlike cells to chondrocytelike cells with the progress of repair. Safranin O stained specimens showed a higher stainability with the progress of repair, confirming that abundant proteoglycan existed. In cases of complete healing, the repair tissue immunostained with antibodies to chondroitin-4-sulfate, chondroitin-6-sulfate, keratan sulfate, and Type II collagen showed a higher stainability than did the surrounding meniscus tissue. Thus, it is possible that the repair tissue might have been hyalinelike cartilage.

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Citations

Jan 18, 2006·In Vitro Cellular & Developmental Biology. Animal·Madhu M BhargavaRussell F Warren
Nov 13, 2007·The Journal of Craniofacial Surgery·Rosalia LeonardiLorenzo Lo Muzio
Jun 12, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·R C BrayP T Salo
Dec 19, 2012·Medicine and Science in Sports and Exercise·Aki OsawaJohnny Huard
Sep 25, 1999·The American Journal of Sports Medicine·J L CookC R Cook
Feb 24, 2001·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·H E KambicC A McDevitt
Mar 9, 2011·The American Journal of Sports Medicine·René VerdonkEva-Lisa Heinrichs
Jun 13, 2001·Clinical Orthopaedics and Related Research·T YasunagaS Kikuchi
Apr 1, 1999·The Journal of Orthopaedic and Sports Physical Therapy·J C Gray
Nov 10, 2006·The American Journal of Sports Medicine·Mena MesihaMartha M Murray
Jan 21, 2000·Archives of Biochemistry and Biophysics·A H PlaasC B Frank
Oct 12, 2004·Biochemical and Biophysical Research Communications·Jochen G HofstaetterMelvin J Glimcher
Jul 21, 2004·Clinics in Sports Medicine·Thomas R BowenMark D Miller

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