Histologic features after surgery associating liver partition and portal vein ligation for staged hepatectomy versus those after hepatectomy with portal vein embolization

Surgery
K MatsuoK Tanaka

Abstract

We compared histologic findings in nonneoplastic portions of liver resected during surgery associating liver partition with portal vein ligation for staged hepatectomy (ALPPS) with those from hepatectomy after portal vein embolization (PVE). Effects of congestion and ischemia in ALPPS on hepatocyte regeneration are incompletely understood, as are those on hepatocyte maturity. Specimens obtained from 8 patients treated with ALPPS and from 14 patients treated with hepatectomy after PVE were examined by light and electron microscopy. Extrapolated kinetic growth of the future liver remnant (FLR) for ALPPS was 14.4 ± 4.8 mL/d, which was faster than for PVE (3.6 ± 2.2 mL/d; P < .001). Microscopically, the FLR showed greater hepatocyte cell density and smaller hepatocyte size in ALPPS than in PVE (P < .01 for each). Bright-appearing hepatocytes and sinusoidal narrowing were more frequent in ALPPS (50% and 50%) than in PVE (0% and 8.3%; P = .025 for each). In the deportalized ventral aspect of the anterior section, hepatocyte atrophy, hepatocyte degeneration or necrosis, sinusoidal dilation, fibrosis, and congestion were more frequent in ALPPS than in PVE (P = .001, P = .002, P < .001, and P < .001, respectively). Electron microscopy f...Continue Reading

References

Nov 3, 2011·World Journal of Surgery·Eduardo de SantibañesVictoria Ardiles
Feb 15, 2012·Annals of Surgery·Eduardo de Santibañes, Pierre-Alain Clavien
Aug 21, 2012·Updates in Surgery·Sofía SalaEduardo de Santibañes
Jun 22, 2013·Cell Division·Yuichiro Miyaoka, Atsushi Miyajima
Dec 18, 2013·Updates in Surgery·Francesca RattiLuca Aldrighetti
Feb 24, 2015·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·K TanakaM Tanabe

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Citations

May 26, 2017·The British Journal of Surgery·J ZhaoUNKNOWN Chemotherapy-Associated Liver Injury (CALI) consortium
Jan 31, 2018·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Daryl Kai Ann ChiaAlfred Wei Chieh Kow
May 3, 2018·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·Ernesto SparrelidBengt Isaksson
May 5, 2018·Annals of Surgery·Hauke LangPierre-Alain Clavien
Sep 28, 2016·World Journal of Gastroenterology : WJG·Demetrios MorisDimitrios Dimitroulis
Oct 9, 2019·Annals of Surgery·Dimitri A RaptisPierre-Alain Clavien
Apr 11, 2020·Surgical Endoscopy·Kawka MichalJiao R Long
Jun 26, 2020·World Journal of Surgical Oncology·Jan BednarschUlf Peter Neumann
Mar 14, 2019·Annals of Hepato-biliary-pancreatic Surgery·Nagappan KumarSameer Junnarkar
Mar 21, 2021·Journal of Hepato-biliary-pancreatic Sciences·Mohammad H Fard-AghaieAndras Fulop
Apr 22, 2021·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Ji-Chao TangYu Zhang
Oct 14, 2018·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Federico TomassiniRoberto I Troisi

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