PMID: 7037148Feb 1, 1982Paper

Histologic grading study of prostate adenocarcinoma: the development of a new system and comparison with other methods--a preliminary study

Cancer
P N BrawnD E Johnson

Abstract

A new grading system for adenocarcinoma of the prostate (MDAH System) and its simplified version, both based on the percentage of tumor that is differentiated (gland-forming) or undifferentiated (non-gland-forming), were compared with the grading systems of Mostofi and Gleason. In a study group of 182 patients with Stage C adenocarcinoma of the prostate, the MDAH system identified 84 patients (46%) as Grade 1, 75 (41%) as Grade 2--3, and 23 (13%) as Grade 4. Kaplan-Meier survival curves predicted a 91% five-year survival for Grade 1 patients, a 60% 5-year survival for Grade 2--3 patients, and a 15% five-year survival for Grade 4 patients. Wilcoxon (Gehan modification) tests showed that the survival was significantly different among Grades 1, 2--3, and 4. The MDAH System is an improvement over other grading systems in that it is a simple, low-power microscopic method that depends only on the percentage of gland formation in the tumor and further reflects the biologic behavior of the tumor as measured by the patient's survival.

References

Feb 1, 1967·The Journal of Urology·G T MellingerJ Bailar

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Citations

Oct 1, 1988·The Journal of Pathology·W A RaymondJ S Jose
Feb 1, 1993·Cancer·F K MostofiC J Davis
Jan 1, 1994·Genes, Chromosomes & Cancer·M G BandykJ C Liang
Dec 10, 1999·Proceedings of the National Academy of Sciences of the United States of America·R S HubertD E Afar
May 30, 2003·The Oncologist·Masood A Khan, Alan W Partin
Sep 11, 2007·World Journal of Urology·Rainer Engers
Nov 23, 2011·International Journal of Urology : Official Journal of the Japanese Urological Association·Burkhard Helpap, Jens Köllermann
Jan 1, 1986·Virchows Archiv. A, Pathological Anatomy and Histopathology·P ChastonayD Gardiol
Jul 15, 1983·Cancer·P N Brawn
Jan 1, 1982·The Prostate·P Albertsen
Jan 13, 2004·The Prostate·Vincent L FreemanRamon Durazo-Arvizu

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