Histologic improvement of NAFLD in patients with obesity after bariatric surgery based on standardized NAS (NAFLD activity score)

Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery
Witigo von SchönfelsClemens Schafmayer

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder in industrialized countries. Nonalcoholic steatohepatitis is the fastest growing cause for liver failure. Bariatric surgery represents a treatment option for NAFLD with an established effect on liver histology. We aimed to assess the impact of bariatric surgery on standardized liver histology using the NAFLD activity score. Retrospective comparison of metabolic data before and after bariatric surgery and comparison of sleeve gastrectomy and Roux-en-Y gastric bypass. The study was performed in an academic center, the university hospital Schleswig-Holstein in Kiel, Germany. Between 2009 and 2012, bariatric surgery was performed in 257 patients according to the national guidelines, and a liver biopsy was obtained in 150 of these patients during surgery. A follow-up biopsy was available in 53 of these patients at a median of 192 days. Liver histology was analyzed using the NAFLD activity score. In this subgroup of 53 patients an analysis of the metabolic improvement after bariatric surgery and a comparative analysis between the 2 different operative procedures was performed. The study cohort showed improvement of preoperative pathologic liver histolo...Continue Reading

Citations

Jan 9, 2019·Obesity Surgery·Iraklis PerysinakisElias Margaris
Feb 28, 2019·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Nazia Selzner, David Grant
Aug 25, 2020·Langenbeck's Archives of Surgery·Benedikt KaufmannDaniel Hartmann
Aug 20, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Giulia AngeliniGeltrude Mingrone
Jan 24, 2019·World Journal of Gastroenterology : WJG·Naoki TanakaEiji Tanaka
Aug 3, 2019·Obesity Surgery·Mohamed Abdalla SalmanMai Elshenoufy
May 27, 2020·Obesity Surgery·Carine LeiteCarlos Thadeu Schmidt Cerski
Oct 4, 2020·Biotechnology and Applied Biochemistry·Mohsen NiksereshtAmir Hossein Doustimotlagh
Oct 8, 2020·Hepatology Communications·Joud ArnoukJaideep Behari
Apr 5, 2021·Obesity Surgery·Sophia M-T SchmitzPatrick H Alizai
Jul 10, 2021·Seminars in Liver Disease·Yuly P MendozaAnnalisa Berzigotti
Mar 30, 2021·Journal of Clinical Gastroenterology·Hannah P KimAlfred Sidney Barritt

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