Histologic investigation of airway inflammation in postmortem lung samples from racehorses

American Journal of Veterinary Research
Fe Ter WoortL Viel

Abstract

OBJECTIVE To describe histologic findings in the small airways during postmortem examination of actively racing horses and to quantify the degree of airway inflammation by use of a semiquantitative scoring system. SAMPLE Lung tissues obtained from 95 horses (Thoroughbreds, Standardbreds, and Quarter Horses) that had been actively racing or training. PROCEDURES 10 standardized lung sections were obtained during postmortem examination of 37 horses that had been actively racing or training, and 2 histologic sections of the caudodorsal lung lobes previously collected from each of 58 horses that died or were euthanized during racing or training were also obtained. Sections were evaluated by use of a validated histologic small airway scoring system. RESULTS Scores for inflammatory cells, smooth muscle, and hemosiderin typically were high. Signalment and cause of death were not significant predictors of lung scores. Lung sample location was a significant predictor, with the highest scores in the caudal and dorsal sections. Inflammatory cell infiltration in peribronchiolar tissues, smooth muscle hyperplasia, and hemosiderin (prevalence of 86%, 98%, and 80%, respectively) were common findings in lungs of these horses, with the caudodors...Continue Reading

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Citations

Jul 22, 2018·Equine Veterinary Journal·W R Cook
Oct 9, 2018·Journal of Veterinary Internal Medicine·Stephanie BondR Scott Pirie
Nov 13, 2019·Cell and Tissue Research·Michela Bullone, Jean-Pierre Lavoie
Apr 30, 2020·Equine Veterinary Journal·Esther M Millares-RamirezJean-Pierre Lavoie
May 21, 2020·Frontiers in Veterinary Science·Gabrielle BrankstonJanet Beeler-Marfisi
Sep 2, 2021·Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere·Ann Kristin Barton, Heidrun Gehlen
Sep 17, 2021·Equine Veterinary Journal·Florence Dupuis-Dowd, Jean-Pierre Lavoie

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