Histologic Lesions Induced by Murine Norovirus Infection in Laboratory Mice

Veterinary Pathology
C C HsuP M Treuting

Abstract

Murine noroviruses (MNVs) are highly prevalent in laboratory mice, can cause persistent infections, and have been shown to infect macrophages, dendritic cells, and B cells. To address the potential impact of MNV infection on research outcomes, numerous studies have been conducted with various mouse models of human disease and have generated mixed results, ranging from no impact to significant disease. Many of these studies included histologic evaluations after MNV infection, and these results have similarly been variable in terms of whether MNV induces lesions, despite the fact that localization of MNV by viral culture and molecular techniques have demonstrated systemic distribution regardless of mouse immune status. The aim of this review is to summarize the histologic findings that have been reported with MNV infection in several mouse models. The studies demonstrate that experimental infection of MNV in wild-type mice results in minimal to no histologic changes. In contrast, immunodeficient mice consistently have detectable MNV-induced lesions that are typically inflammatory and, in the most severe cases, accompanied by necrosis. In these, the liver is commonly affected, with more variable lesions reported in the lung, gastr...Continue Reading

References

Mar 8, 2003·Science·Stephanie M KarstHerbert W Virgin
Sep 6, 2005·Journal of Virology·Santiago F Elena, Rafael Sanjuán
May 16, 2006·Journal of Virology·Christiane E WobusHerbert W Virgin
Nov 1, 2006·Toxicologic Pathology·Jerrold M WardKim Y Green
Dec 16, 2006·Virus Genes·Charlie C HsuRobert S Livingston
Dec 20, 2007·The Journal of General Virology·Richard E Randall, Stephen Goodbourn
Feb 26, 2008·The Veterinary Journal·A ScipioniE Thiry
Aug 5, 2008·Veterinary Microbiology·Sandro WolfGail E Greening
Aug 6, 2008·Emerging Infectious Diseases·Vito MartellaCanio Buonavoglia
Nov 19, 2008·Laboratory Animals·Kathleen R Pritchett-CorningCharles B Clifford
Nov 21, 2009·Seminars in Immunology·Philip RosenstielStefan Schreiber
Dec 29, 2010·The Journal of Veterinary Medical Science·Jong Rhan KimByeong-Cheol Kang
Jan 18, 2011·Comparative Immunology, Microbiology and Infectious Diseases·Peter D R HigginsChristiane E Wobus
Mar 1, 2010·Viruses·Stephanie M Karst
Jan 20, 2012·Journal of Virology·Søren Jensen, Allan Randrup Thomsen
Oct 23, 2012·Journal of Virology·Herman TseKwok-Yung Yuen
Jul 19, 2013·MBio·Stefan TaubeChristiane E Wobus
Nov 15, 2013·The Journal of General Virology·Amita ShortlandJonathan L Heeney
Feb 4, 2014·Inflammatory Bowel Diseases·Marijana BasicAndré Bleich
Jun 13, 2014·Cell Host & Microbe·Stephanie M KarstHerbert W Virgin
Oct 15, 2014·The Journal of Pathology·Stephanie M KarstIan G Goodfellow
Nov 8, 2014·Science·Melissa K JonesStephanie M Karst
Nov 20, 2014·Nature·Elisabeth KernbauerKen Cadwell

❮ Previous
Next ❯

Citations

Feb 17, 2017·Veterinary Pathology·P M Treuting, C Hsu
Feb 17, 2017·Veterinary Pathology·H J Van Kruiningen
Dec 19, 2020·Frontiers in Veterinary Science·Zhao NaLi Shuang
Dec 14, 2019·Cancer Immunology Research·Karin SchreiberMatthias Leisegang

❮ Previous
Next ❯

Methods Mentioned

BETA
AALAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.