PMID: 319141Feb 1, 1977Paper

Histologic responses in human skin test reactions to ragweed. IV. Effects of a single intravenous injection of steroids

The Journal of Allergy and Clinical Immunology
E H DunskyB Zweiman

Abstract

A controlled study has been carried out dealing with the early effects of a single intravenous dose of either methylprednisolone or placebo or newly developed and ongoing cellular inflammatory responses in immediate hypersensitivity skin test reactions. There was no significant difference in the tissue eosinophil responses to ragweed injected 2 hr before and 2 hr after placebo; there was a significant rise (101% +/- 39) from the second to fourth hour after antigen injection. By contrast, there was a marked decrease in the tissue eosinophil response to antigen injected 2 hr after steroids as compared to the pattern seen in the presteroid reaction. In addition, the eosinophil numbers not only did not increase from the second to fourth hour when steroids were injected at the second hour but decreased markedly. These findings suggest early suppressive effects on tissue eosinophil responses within 2 hr after steroid were administered intravenously. Also, there may be trafficking of eosinophils both into and out of these inflammatory sites during the first hours after intradermal antigen injection.

Citations

Jul 11, 1985·The New England Journal of Medicine·R M NaclerioL M Lichtenstein
Oct 1, 1993·British Journal of Pharmacology·C Zuany-AmorimM Pretolani
Jan 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S Ollier
Jan 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C De Vos
Oct 1, 1979·The Journal of Allergy and Clinical Immunology·P C AtkinsF Rosenblum
Jun 11, 1987·The New England Journal of Medicine·U PipkornR M Naclerio
Jan 1, 1993·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·M K Church

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