PMID: 2492898Mar 15, 1989Paper

Histologic tumor regression grades in squamous cell carcinoma of the head and neck after preoperative radiochemotherapy

Cancer
O M BraunJ H Holzner

Abstract

Forty-one patients with Stage III and IV squamous cell carcinomas (SCC) of the head and neck were treated preoperatively with mitomycin C and 5-fluorouracil and concomitant radiotherapy. Operation specimen were examined histologically, the percentage of vital tumor cells and devitalized tumor cells were graduated. The grade of regression was classified according to a four-stage scale. Tumor regression was elevated as good (Grades 1, 2) and bad (3, 4) response to combined preoperative therapy. After a follow-up of 18 to 30 months, 14 of 41 patients have experienced a locoregional recurrence; all these patients were bad responders (Grades 3, 4) to preoperative radiochemotherapy. There was a statistically significant correlation between tumor regression grade and probability of survival (P less than 0.001). The authors conclude that the prognosis of patients with pretreated SCC of head and neck depends on the histologic grade of tumor regression.

Citations

Jan 1, 1993·Cancer Chemotherapy and Pharmacology·G FranciniS Gonnelli
May 15, 2009·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Oliver DriemelHans Pistner
Mar 19, 2008·Transplantation·Christian KermerMichael Oeckher
Dec 26, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yuki YamaneAtsushi Ochiai
Nov 15, 1993·International Journal of Radiation Oncology, Biology, Physics·T AraiK Oka
Mar 6, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M CaricatoR Coppola
Jan 1, 1993·Acta Oto-laryngologica. Supplementum·T TachikawaS Kohnoe
Oct 26, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Claus RödelChristian Wittekind
May 23, 2019·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Wenxue LiuHaiping Pei
Apr 28, 2020·Cancer Control : Journal of the Moffitt Cancer Center·Rajab AlzahraniMajed Alghamdi
Apr 7, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Enrique CasadoPaloma Cejas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.