Histological analysis of achilles tendons in an overuse rat model

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Mark A GlazebrookJ Michael Lee

Abstract

The purpose of this study was to design an animal model that induces histological changes in Achilles tendons consistent with those cited in the literature for human Achilles tendon disease. Sprague-Dawley rats were subjected to 10 degrees uphill treadmill running on a custom-designed rodent treadmill and at a speed of 17 meters per minute for 1 h, five times per week, over a 12-week treatment period. Subsequent histological analysis revealed alterations in the rat Achilles tendon that were generally consistent with those described in the literature for diseased human tendon tissues. These features include: decreased collagen fiber organization, more intense collagen staining, and increased cell nuclei numbers. Interestingly, though, immunohistochemical cell typing suggests that the observed increased cellularity does not include a significant inflammatory component but is secondary to increased numbers of endothelial cells (i.e., vascularization) and fibroblasts. These histological features likely represent a biological repair/remodeling response resulting from overuse running.

References

Jul 1, 1976·The American Journal of Sports Medicine·G PudduF Postacchini
Jan 11, 1975·Clinical Orthopaedics and Related Research·J M FoxG J Carlson
Sep 1, 1990·Journal of Applied Physiology·W T StauberW J Evans
Jul 1, 1990·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·C BackmanG Toolanen
Jan 1, 1989·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·T F HitchcockA D Blevens
Jan 1, 1967·Acta Orthopaedica Scandinavica·R Ljungqvist
Jan 1, 1984·Archives of Orthopaedic and Trauma Surgery·L JózsaZ Demel
Apr 1, 1984·International Journal of Sports Medicine·J Fridén
Apr 1, 1980·Annals of the Rheumatic Diseases·R J Minns, F S Steven
Sep 1, 1996·Journal of Shoulder and Elbow Surgery·L J SoslowskyM R Moalli
Apr 1, 1997·Acta Orthopaedica Scandinavica·T MovinC Rolf
Aug 26, 1998·Medicine and Science in Sports and Exercise·L C Almekinders, J D Temple
Dec 16, 1998·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·N MaffulliG Puddu
Dec 16, 1998·The American Journal of Sports Medicine·J E CarpenterL J Soslowsky
Mar 4, 1999·Medicine and Science in Sports and Exercise·N Maffulli, K M Kahn
Apr 30, 1999·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·D StoneS L Woo
Aug 26, 1999·Cells, Tissues, Organs·K MessnerT Räsänen
Oct 20, 1999·Medicine and Science in Sports and Exercise·J L McCroryS P Messier
Nov 5, 1999·Clinical Orthopaedics and Related Research·J E CarpenterL J Soslowsky
Dec 2, 2000·The American Journal of Sports Medicine·N MaffulliS W Ewen
Dec 31, 2003·Biomaterials·James E Carpenter, Kurt D Hankenson
Apr 21, 2004·Annals of Biomedical Engineering·Tung-Fu HuangLouis J Soslowsky
Jan 1, 1988·The Journal of Orthopaedic and Sports Physical Therapy·S FriederA Stanek

❮ Previous
Next ❯

Citations

Feb 14, 2013·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Eva RunessonBengt I Eriksson
Jan 13, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Dorthe SkovgaardAndreas Kjaer
Apr 10, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Dorthe SkovgaardAndreas Kjaer
Mar 19, 2013·BMC Musculoskeletal Disorders·Rachel C DirksStuart J Warden
Dec 15, 2010·Sports Medicine, Arthroscopy, Rehabilitation, Therapy & Technology : SMARTT·Sai-Chuen FuKai-Ming Chan
Aug 27, 2013·PloS One·Jianying Zhang, James H-C Wang
Jun 14, 2013·Connective Tissue Research·Marco FranchiMilena Fini
May 20, 2011·Connective Tissue Research·Gabriel Yin-Fat NgRoy Tsz-Hei Cheung
Jan 17, 2012·Journal of Shoulder and Elbow Surgery·Megan L KillianStavros Thomopoulos
May 12, 2009·Journal of Neuroscience Methods·Sai-Chuen FuPo-Yee Pauline Lui
Oct 17, 2015·The Journal of Orthopaedic and Sports Physical Therapy·Christian CouppéS Peter Magnusson
Mar 2, 2013·Equine Veterinary Journal·J A CadbyH T M van Schie
Jul 11, 2013·International Journal of Experimental Pathology·Jennifer H Shepherd, Hazel R C Screen
Aug 3, 2010·Scandinavian Journal of Medicine & Science in Sports·P P Y LuiR K W Smith
Jul 31, 2013·Scandinavian Journal of Medicine & Science in Sports·J PingelA Scott
Nov 5, 2008·Scandinavian Journal of Medicine & Science in Sports·R BaroneG Zummo
Aug 21, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yen-Ting WuI-Ming Jou
May 7, 2015·Scandinavian Journal of Medicine & Science in Sports·S I DockingJ Cook
Dec 19, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Yun-Pu TsaiChun-I Sze
Feb 13, 2014·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Richard StangeVolker Vieth
Jun 20, 2016·Academic Radiology·Timm DirrichsSimone Schrading
Aug 28, 2016·Histochemistry and Cell Biology·Christian CouppéPeter Schjerling
Mar 24, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Xin PangThomas Brett Kirk
Jun 10, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Tyler W Herod, Samuel P Veres
Jan 18, 2018·Journal of Cellular Physiology·Sun Jeog KimSang Jun Kim
Oct 5, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Bhavani P Thampatty, James H-C Wang
Jun 20, 2018·The Journal of Physiology·S Peter Magnusson, Michael Kjaer
Jul 30, 2011·Clinical Orthopaedics and Related Research·Nam Soon ChoSeoung Wan Chae
Mar 24, 2010·Nature Reviews. Rheumatology·S Peter MagnussonMichael Kjaer
Mar 29, 2019·Diabetic Medicine : a Journal of the British Diabetic Association·N E HillS Chew
Dec 9, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ross M PotterChad C Carroll
Nov 4, 2009·The Journal of Bone and Joint Surgery. American Volume·Chisa HidakaScott Rodeo
Apr 8, 2020·Journal of Biomechanical Engineering·Mengcun ChenLouis J Soslowsky
Jan 18, 2017·PloS One·Rodrigo Ribeiro de OliveiraGerly Anne de Castro Brito
Sep 27, 2020·International Journal of Molecular Sciences·Christelle Darrieutort-LaffiteBenoit Le Goff

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.