Histological analysis of lymphocyte subsets infiltrated into mouse tumor tissue exposed to local irradiation

Oncology
S HirotaH Seguchi

Abstract

The subsets of lymphocytes infiltrated into mouse tumor tissue exposed to irradiation were analyzed by the avidin-biotin-peroxidase procedure using monoclonal antibodies. The effect of PSK administration was also analyzed. Microscopic observation revealed the intense lymphocytic reactions in the exposed tumor, especially 7 days after irradiation of 20 Gy, which mainly consisted of anti-L3T4 positive cells, whereas the degree of infiltration was lower in the nonexposed tumor. PSK was found to enhance T lymphocyte subset infiltration into the exposed tumor tissue.

Citations

Jun 1, 1990·International Journal of Radiation Oncology, Biology, Physics·Y OgawaG K Lam
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D De RuysscherE van der Schueren
Dec 1, 2006·Veterinary and Comparative Oncology·D H Thamm
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amit A LugadeEdith M Lord

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