Histological and clinical characteristics of malignant giant cell tumor of bone.

Virchows Archiv : an International Journal of Pathology
Lihua GongXiaoyuan Huang

Abstract

Malignant giant cell tumors of bone (MGCTB) are rare, and the diagnosis can be difficult due to the occurrence of a variety of malignant tumors containing giant cells. To better understand its clinicopathological features, we have reviewed our experience with 17 cases of MGCTB. Five cases were primary malignant giant cell tumor of bone (PMGCTB), and 12 cases were giant cell tumors of bone initially diagnosed as benign but malignant in a recurrent lesion (secondary MGCTB, SMGCTB). The patients included six women and 11 men (age ranged from 17 to 52 years; mean, 30.5 years). The tumor arose in the femur (six cases), the tibia (seven cases), the humerus (three cases), and the fibula (one case). Microscopically, PMGCTB showed both conventional giant cell tumor and malignant sarcoma features. SMGCTB were initially diagnosed as conventional giant cell tumor of bone, the recurrent lesion showing malignant features. Histologically, the malignant components included osteosarcoma (11 cases), undifferentiated high-grade pleomorphic sarcoma (two cases), and fibrosarcoma (four cases). SMGCTB cases showed strong expression of p53. Follow-up information revealed that four patients died of lung metastasis, two patients are alive with lung meta...Continue Reading

References

Apr 5, 1972·Nature: New Biology·F Lund, L Tybring
May 1, 1970·Cancer·D C DahlinE W Johnson
Jan 1, 1995·Skeletal Radiology·S KenanM M Lewis
Feb 1, 1997·The Journal of Bone and Joint Surgery. American Volume·R J SakkersP C Hogendoorn
Mar 2, 1999·Archives of Pathology & Laboratory Medicine·L J LayfieldJ M Mirra
Apr 20, 2001·Skeletal Radiology·T MaruiT Akamatsu
May 7, 2003·Cancer·Franco BertoniEric L Staals
Sep 13, 2005·Human Pathology·Yu Sin LauNicholas Athanasou
Feb 19, 2008·The Journal of Pathology·R G ForsythP C W Hogendoorn
Sep 5, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ramses G ForsythPancras C W Hogendoorn
Nov 11, 2009·Annals of Surgical Oncology·Stepan V Domovitov, John H Healey
Dec 17, 2009·Virchows Archiv : an International Journal of Pathology·M AlberghiniN A Athanasou
Mar 3, 2010·Journal of Neurosurgery. Pediatrics·Petros N KaramanakosArto Immonen
May 13, 2011·Journal of Clinical Pathology·F MaggianiN A Athanasou

❮ Previous
Next ❯

Citations

Sep 12, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lindsey C WuAmy Berrington de González
Apr 10, 2016·Cancer Epidemiology·Justyna M AmelioAlexander Liede
Oct 16, 2012·Bone·Robert W Cowan, Gurmit Singh
Aug 26, 2014·Revista española de cirugía ortopédica y traumatología·F AbatI Grácia
Mar 20, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nicole A KarrasEmily Lipsitz
May 16, 2017·The American Journal of Surgical Pathology·Fernanda AmaryAdrienne M Flanagan
Apr 3, 2019·Technology in Cancer Research & Treatment·Emanuela PalmeriniGerald Downey
Jun 12, 2013·Virchows Archiv : an International Journal of Pathology·Taketo OkuboTakashi Yao
Nov 6, 2018·Acta orthopaedica et traumatologica turcica·Nil ÇomunoğluSergülen Dervişoğlu
Nov 6, 2015·The Journal of Bone and Joint Surgery. American Volume·Julia RockbergAlexander Liede
Nov 22, 2019·Medical Molecular Morphology·Hidetaka YamamotoYoshinao Oda
Nov 30, 2019·Head and Neck Pathology·Avani JainDeepti Varshney
Jun 5, 2015·Journal of Neuro-oncology·Huabin YinJianru Xiao
Jun 1, 2017·Nuclear Medicine and Molecular Imaging·Hye Lim ParkChan Kwon Jung
Sep 29, 2015·The American Journal of Surgical Pathology·John WojcikVikram Deshpande
Oct 23, 2020·Cytopathology : Official Journal of the British Society for Clinical Cytology·Parikshaa GuptaArvind Rajwanshi
Oct 31, 2020·Frontiers in Oncology·Hengyuan LiZhaoming Ye
Dec 1, 2020·Journal of Bone Oncology·Weifeng LiuXiaohui Niu
Jan 23, 2021·Advances in Anatomic Pathology·Joon Hyuk Choi, Jae Y Ro
Nov 15, 2020·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Lucas Alves da Mota SantanaCleverson Luciano Trento
Dec 14, 2018·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Makoto EmoriToshihiko Yamashita

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.