Histological and immunological differences between zoonotic cutaneous leishmaniasis due to Leishmania major and sporadic cutaneous leishmaniasis due to Leishmania infantum

Parasite : Journal De La Société Française De Parasitologie
Thouraya BoussoffaraHechmi Louzir

Abstract

Lesion features in cutaneous leishmaniasis (CL) depend on the infecting Leishmania species as well as on host immune reponse. In this study, we evaluated the histological and immunological differences between two forms of CL described in Tunisia: zoonotic cutaneous leishmaniasis (ZCL) caused by L. major and sporadic cutaneous leishmaniasis (SCL) caused by L. infantum. Histological analysis showed a mild to moderate infiltrate within ZCL lesions. In contrast, massive infiltration of the dermis was observed within SCL lesions. Contrary to ZCL, infiltrates within SCL lesions were organized and showed granuloma composed of macrophages and lymphocytes. In addition, immunohistochemical analysis showed a predominance of CD4+ T cells within both CL forms. Furthermore, expression of interferon-γ, interleukin (IL)-10, IL-8, IL-13 and monocyte chemotactic protein (MCP)-1 was evaluated using real-time quantitative polymerase chain reaction (RT-qPCR). MCP-1 and IL-10 were expressed at comparable levels in ZCL and SCL lesions. Interestingly, IL-8 mRNA levels were significantly higher in ZCL lesions compared to SCL lesions, but interferon-γ was significantly higher in SCL lesions than in ZCL lesions.

References

Nov 1, 1987·Scandinavian Journal of Immunology·R Nilsen, R N Mshana
Mar 1, 1993·Clinical and Experimental Immunology·G Cáceres-DittmarJ Convit
Apr 1, 1993·The Journal of Clinical Investigation·C PirmezR L Modlin
Feb 12, 1998·The New England Journal of Medicine·A D Luster
Mar 5, 2002·Clinical and Diagnostic Laboratory Immunology·Alda Maria Da-CruzSergio G Coutinho
May 1, 2002·Journal of Clinical Microbiology·Luc NicolasGeneviève Milon
Jul 10, 2002·Parasite Immunology·Uwe Ritter, Heinrich Körner
Apr 15, 2005·Parasite : Journal De La Société Française De Parasitologie·A BouratbineS Etlijani
Aug 9, 2005·Immunology Letters·Lis R V AntonelliKenneth J Gollob
Nov 29, 2005·Cellular Microbiology·Phillip Scott
Nov 29, 2005·Trends in Parasitology·Maria Jania TeixeiraAldina Barral
Dec 17, 2005·Transactions of the Royal Society of Tropical Medicine and Hygiene·Moncef BenSaidIkram Guizani
Jun 27, 2007·International Journal of Epidemiology·Afif Ben SalahPoulicos Prastacos
Aug 24, 2007·The Lancet Infectious Diseases·Richard ReithingerSimon Brooker
Oct 16, 2007·Parasite : Journal De La Société Française De Parasitologie·N HaouasH Babba
Mar 20, 2010·Journal of Biomedicine & Biotechnology·Hannah E CummingsAbhay R Satoskar
Nov 3, 2010·The American Journal of Tropical Medicine and Hygiene·Nadia BousslimiAïda Bouratbine
Apr 19, 2011·Annales de dermatologie et de vénéréologie·M MokniS Boubaker
May 25, 2011·The Journal of Experimental Medicine·Ricardo GoncalvesDavid M Mosser
Sep 27, 2012·Parasite Immunology·S Nylén, L Eidsmo
Oct 3, 2013·Molecular Immunology·Matheus Fernandes Costa-SilvaAndréa Teixeira-Carvalho
Mar 15, 2014·Parasite : Journal De La Société Française De Parasitologie·Karim Aoun, Aïda Bouratbine
Mar 15, 2014·Anais Brasileiros De Dermatologia·Ana Luiza Grizzo Peres MartinsAna Claudia Grizzo Peres Martins
Aug 22, 2014·Parasites & Vectors·Jihene BettaiebAfif Ben Salah
Jul 19, 2016·Nature Reviews. Immunology·Phillip Scott, Fernanda O Novais

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Citations

Mar 11, 2020·Seminars in Immunopathology·Paul M KayeSimon L Croft
May 1, 2021·International Journal of Molecular Sciences·Alberto A Robles-LoaizaJosé R Almeida
May 3, 2021·Medical Microbiology and Immunology·Mahmoud Nateghi Rostami, Ali Khamesipour
Apr 30, 2021·Parasite Immunology·Fatemeh DarziMahmoud Nateghi Rostami
Aug 1, 2021·Anais Brasileiros De Dermatologia·Camila Sampaio RibeiroPaulo R L Machado

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Methods Mentioned

BETA
biopsies
biopsy
electrophoresis
PCR

Software Mentioned

- Pad Prism
Graph

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