Histological and molecular characterization of intrahepatic bile duct cancers suggests an expanded definition of perihilar cholangiocarcinoma

HPB : the Official Journal of the International Hepato Pancreato Biliary Association
Masayuki AkitaYoh Zen

Abstract

Growing evidence has suggested that intrahepatic cholangiocarcinoma (iCCA) can be classified into small- and large-duct types. The present study aimed to elucidate how large-duct iCCA is similar and dissimilar to perihilar cholangiocarcinoma (pCCA). The study cohort consisted of iCCA (n = 58) and pCCA (n = 44). After iCCA tumors were separated into small- (n = 36) and large-duct (n = 22) types based on our histologic criteria, genetic statuses of the three types of neoplasms were compared. Locations of iCCA were plotted on a three-dimensional image and their distances from the portal bifurcation were measured. Large-duct iCCA was distinct from small-duct iCCA in terms of frequency of bile duct reconstruction required, perineural infiltration, and survival, with these features more similar to pCCA. Large-duct iCCA and pCCA more frequently had the loss of SMAD4 expression and MDM2 amplifications than small-duct iCCA, whereas the loss of BAP1 expression and IDH1 mutations were mostly restricted to small-duct iCCA. From imaging analysis, most tumors of large-duct iCCA were present around the second branches of the portal vein. Large-duct type iCCA shared the molecular features with pCCA, and it may be reasonable to expand the defin...Continue Reading

Citations

Jul 25, 2019·The American Journal of Surgical Pathology·Mariko TanakaMasashi Fukayama
Aug 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fabiana CrispoMatteo Landriscina
Oct 2, 2020·Biomolecules·Yu-Chan ChangMichael Hsiao
Aug 23, 2020·Cancers·Annamaria MassaMassimo Aglietta
Oct 21, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kyohei YugawaMasaki Mori
Mar 3, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yongjie ZhouHong Bu
Apr 23, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jihoon G YoonYoung Nyun Park
Sep 11, 2021·Nature Reviews. Disease Primers·Paul J BrindleyGregory J Gores

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