PMID: 9447940Feb 3, 1998Paper

Histological and physiological effects of the central auditory prosthesis: surface versus penetrating electrodes

Hearing Research
X LiuG M Clark

Abstract

To rehabilitate profoundly deaf patients who are not suitable for cochlear implants, central auditory prostheses have been implanted. To compare two possible electrode configurations - penetrating and surface ones - electrical stimulation of the cochlear nucleus with both types of arrays was tested on guinea pigs and cats. Electrophysiological, autoradiographic and histological measures were used to study effects of the central auditory prostheses on the auditory pathway. The results showed that a successful electrically evoked auditory brainstem response could be recorded with both surface and penetrating electrodes in cats and guinea pigs. In guinea pigs the penetrating electrodes had advantages over surface arrays in the sense of lower thresholds and wider dynamic ranges. In cats penetrating electrodes showed lower thresholds than surface ones. In cats and guinea pigs stimulated with either surface or penetrating electrodes, evoked 2-deoxyglucose (2-DG) label was found in the auditory pathway from the cochlear nucleus to the inferior colliculus. No non-auditory tissues were found with evoked 2-DG label. Histological results showed that in subdivisions of the guinea pig cochlear nucleus stimulated with penetrating electrodes ...Continue Reading

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Citations

Aug 5, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Xiaoyun FangYasuo Tano
Mar 4, 2008·Journal of Neural Engineering·Gerwin Schalk
Oct 3, 2000·Journal of Neurosurgery·S K RosahlM Samii
Jun 14, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Kiyoshi OdaToshimitsu Kobayashi
Jan 22, 2008·Hearing Research·D B McCreery
Jul 27, 2005·IEEE Transactions on Bio-medical Engineering·Hirokazu TakahashiKimitaka Kaga
Nov 29, 2007·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Minoo LenarzAlexandru C Stan

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