Histological and transcriptomic responses of two immune organs, the spleen and head kidney, in Nile tilapia (Oreochromis niloticus) to long-term hypersaline stress

Fish & Shellfish Immunology
Chang XuLiqiao Chen

Abstract

Hyperosmotic stress can adversely affect fish immunity, but little is known about the histological and transcriptomic responses of immune organs in fish in a hyperosmotic environment. This study evaluated the effects of long-term hypersaline conditions (16‰) on the growth, histology and transcriptomics of the two main immune organs, the spleen and head kidney, in Nile tilapia Oreochromis niloticus relative to those reared in freshwater for eight weeks. No differences in weight gain and specific growth rate were found between fish reared under these two salinities. Hyperosmotic stress induced a congestive or enlarged spleen. Platelet- and coagulation-related gene expression was significantly decreased in tilapia at 16‰. The red cell distribution width and value of the mean corpuscular hemoglobin were significantly greater in fish at 16‰ salinity than in control fish in freshwater. A large volume of melano-macrophages in the spleen and pigment deposition in both the spleen and head kidney were observed in the histological sections in fish at 16‰ salinity. Transmission electron microscopic results showed abnormal macrophages with deposition granules in the spleen and head kidney and more neutrophils in the head kidney of fish at 1...Continue Reading

Citations

Mar 17, 2020·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Nicollas Breda LehmannMauricio Laterça Martins
Feb 5, 2021·International Journal of Molecular Sciences·Sumali PandeyBrian D Wisenden
Feb 21, 2021·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Quanquan CaoShaowu Yin

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