Histological and ultrastructural effects of cyclosporin A on normal human skin xenografted on to nude mice

Virchows Archiv. A, Pathological Anatomy and Histopathology
J KanitakisJ Thivolet

Abstract

Cyclosporin A (CsA) is a potent immunosuppressant with a selective activity on T-helper lymphocytes. However, CsA also exerts biological effects on non-lymphoid cells (fibroblasts, endothelial and epithelial cells). CsA can inhibit in vivo and in vitro DNA synthesis of epidermal keratinocytes (EK) and induces in vivo morphological alterations of kidney epithelial cells. In the present study we investigated the in vivo effects of a short-term CsA treatment (50 mg/kg per day) on DNA synthesis (evaluated through 5-bromo-2'-deoxyuridine incorporation) and on the histological features of normal human skin xenografted (NHSX) on to congenitally athymic nude mice. When compared with control NHSX, CsA induced a statistically significant inhibition of DNA synthesis of NHSX EK. At the light- and electron-microscopic level, apart from a decrease in the thickness of the viable epidermis of NHSX (statistically non-significant), no noticeable differences between treated and control NHSX could be detected. EK, Langerhans cells and melanocytes appeared morphologically unaffected by CsA and no signs of acute toxicity (giant mitochondria, vacuolization, microcalcifications) were seen. These results suggest that CsA exerts a subtle effect on human...Continue Reading

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Citations

Jan 1, 1992·Archives of Dermatological Research·C AmsellemJ Thivolet
Jul 1, 1992·British Journal of Plastic Surgery·J Nanchahal, C M Ward
Mar 21, 2009·Human Gene Therapy·Joost H van den BergJohn B A G Haanen
Apr 26, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Barbara GeusensJo Lambert
Dec 7, 2005·Ageing Research Reviews·François BrégégèreBertrand Friguet

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