Histological and Ultrastructure Study of the Testes of Acrylamide Exposed Adult Male Albino Rat and Evaluation of the Possible Protective Effect of Vitamin E Intake

Journal of Microscopy and Ultrastructure
Nawal Awad HasaninSara Ahmed Al-Sherief

Abstract

Acrylamide (AA) is a hazardous unavoidable gonadal toxin. Hence, the aim of this study is to clarify its harmful effects on the testis of adult albino rat by light and electron microscope and to evaluate the possible role of Vitamin E (Vit E) in the prevention of such effects. Thirty-five adult male albino rats were enrolled in this study. They were divided into three groups: Group I (control); Group II (AA exposed), and Group III (AA and concomitant Vit E treated group). Animals of Groups II and III were further subdivided into two equal subgroups (each subgroup included five rats): (a) rats were sacrificed after 4 weeks and (b) rats were sacrificed after 6 weeks. The testes of each rat were dissected out, processed, and examined by Hematoxylin and Eosin, Periodic acid-Schiff and Mallory's trichrome stains as well as electron microscopic study. The study revealed that AA induces testicular damage at the histological and ultrastructural level in the form of degeneration and arrested spermatogenesis. Moreover, decreased seminiferous tubules diameters and epithelial height were detected. These changes are maximally improved in Vit E treated group. Hence, we could conclude that AA causes degenerative changes of the testes of albin...Continue Reading

References

Apr 20, 2010·Biostatistics·Paola BortotBruno Scarpa
Nov 8, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yu YanChun-Fu Wu
May 17, 2012·British Journal of Cancer·D KitchenN Rohatgi
Oct 10, 2013·Cellular and Molecular Neurobiology·Hasan TurkezAntonio Di Stefano

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Citations

Apr 25, 2020·Toxicology and Industrial Health·Ozal UlfanovEsat Adiguzel
May 20, 2020·Journal of Toxicologic Pathology·Khaled RadadRudolf Moldzio
Jul 27, 2021·Andrologia·Mehmet GülNurcan Göktürk

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